https://scholars.lib.ntu.edu.tw/handle/123456789/478316
標題: | Lymphopenia is associated with neuropsychiatric manifestations and disease activity in paediatric systemic lupus erythematosus patients | 作者: | HSIN-HUI YU LI-CHIEH WANG Lee J.-H. CHIEN-CHANG LEE YAO-HSU YANG BOR-LUEN CHIANG |
公開日期: | 2007 | 卷: | 46 | 期: | 9 | 起(迄)頁: | 1492-1494 | 來源出版物: | Rheumatology | 摘要: | Objectives. To investigate if lymphopenia is associated with clinical manifestations, disease activity and prognosis in systemic lupus erythematosus (SLE). Methods. The charts of 186 paediatric patients with SLE diagnosed between 1985 and 2006 in a medical centre were retrospectively reviewed. Lymphocyte counts were recorded at the time of SLE diagnosis and SLE flares. Global disease activity was quantified by the SLE Disease Activity Index (SLEDAI). Cumulative organ damage was assessed by the ACR/Systemic Lupus International Collaborating Clinics (SLICC) damage index. Results. Lymphopenia (<1500/mm3) and marked lymphopenia (<500/mm3) was observed in 62.8 and 12.2% at the time of SLE diagnosis. At the time of SLE diagnosis, lymphopenia was significantly associated with oral ulcers, leucopenia, anti-dsDNA antibodies and C4 decrease. At the time of flares, lymphopenia was significantly associated with anti-dsDNA antibodies, methylprednisolone pulse therapy, disease activity and organ damage. Using multivariate logistic regression, marked lymphopenia was independently associated with neuropsychiatric manifestations [odds ratio (OR) 7.41, 95% confidence interval (CI) 1.99-27.0], and protective from LN (OR 0.13, 95% CI 0.03-0.53). Conclusions. Lymphopenia at SLE flares is associated with disease activity and organ damage. Marked lymphopenia is independently associated with neuropsychiatric manifestations. ? The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/478316 | ISSN: | 1462-0324 | DOI: | 10.1093/rheumatology/kem182 | SDG/關鍵字: | azathioprine; complement component C4; cyclophosphamide; cyclosporin; double stranded DNA antibody; hydroxychloroquine; immunoglobulin; methylprednisolone; adolescent; antibody detection; article; child; clinical feature; confidence interval; correlation analysis; corticosteroid therapy; disease activity; disease association; disease exacerbation; disease severity; drug pulse therapy; female; human; hypocomplementemia; leukopenia; lupus erythematosus nephritis; lymphocyte count; lymphocytopenia; major clinical study; male; mental disease; mouth ulcer; multivariate logistic regression analysis; neuropsychiatry; priority journal; prognosis; quantitative analysis; retrospective study; systemic lupus erythematosus; Adolescent; Antibodies, Antinuclear; Child; Child, Preschool; DNA; Female; Humans; Lupus Erythematosus, Systemic; Lupus Vasculitis, Central Nervous System; Lymphopenia; Male; Retrospective Studies; Risk Factors; Severity of Illness Index |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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