https://scholars.lib.ntu.edu.tw/handle/123456789/478445
標題: | Incidence and risk factors associated with bilateral breast cancer in area with early age diagnosis but low incidence of primary breast cancer: Analysis of 10-year longitudinal cohort in Taiwan | 作者: | WEN-HUNG KUO Yen A.M.-F. PO-HUANG LEE Hou M.-F. Chen S.-C. Chen K.-M. Chen, Tony Hsiu Hsi KING-JEN CHANG |
公開日期: | 2006 | 卷: | 99 | 期: | 2 | 起(迄)頁: | 221-228 | 來源出版物: | Breast Cancer Research and Treatment | 摘要: | This study aims to examine the incidence and risk factors of bilateral breast cancer in area with low incidence rate. A total of 120 and 1902 women with bilateral and unilateral breast cancers were enrolled; various factors, including those concerning their medical history and life style, were extracted. Using Kaplan-Meier method, we calculate the cumulative incidence of contralateral breast cancer. The results show as follows. The cumulative incidences of contralateral breast cancer at 1, 3, 5 years after diagnosis of first breast cancer were 1.15, 1.94, and 2.97%, respectively. The statistically significant risk factors included menopause (Hazard Ratio (HR) =1.56, (1.00-2.42)), invasive lobular carcinoma (HR=2.98, (1.35-6.56)), receiving chemotherapy (HR=2.21, (1.43-3.42)) and/or radiotherapy (HR=3.32, (2.19-5.05) and a protective factor was tamoxifen therapy (HR=0.5 (0.34-0.74). Size of the second occurred tumour (2.97 cm) tended to be smaller than the first one (3.58 cm) with borderline statistical significance (p=0.0731). Comparing to the existing data on Western countries, we find a higher risk for developing contralateral breast cancer in Taiwan where a low incidence of first breast cancer rate with early age diagnosis is noted. It suggests that first primary breast tumour with early age of onset and lobular carcinoma are found more likely to develop bilateral breast cancers. ? Springer 2006. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33747610378&doi=10.1007%2fs10549-006-9194-z&partnerID=40&md5=9c073e98520e05ee3260e7d988b635be https://scholars.lib.ntu.edu.tw/handle/123456789/478445 |
ISSN: | 0167-6806 | DOI: | 10.1007/s10549-006-9194-z | SDG/關鍵字: | tamoxifen; adult; anamnesis; article; breast cancer; cancer chemotherapy; cancer diagnosis; cancer incidence; cancer radiotherapy; cancer risk; controlled study; data extraction; female; human; invasive carcinoma; Kaplan Meier method; lung carcinoma; major clinical study; menopause; priority journal; statistical significance; Taiwan; Adult; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Lobular; Cohort Studies; Female; Humans; Incidence; Longitudinal Studies; Lymphatic Metastasis; Menopause; Middle Aged; Risk Factors; Taiwan; Time Factors |
顯示於: | 醫學系 |
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