Sequence variants of peroxisome proliferator-activated receptor-gamma gene and the clinical courses of patients with end-stage renal disease
Journal
Disease Markers
Journal Volume
2015
Pages
763459
Date Issued
2015
Author(s)
Hu F.-C.
Chang C.-C.
Abstract
Background. PPARγ-γ single nucleotide polymorphisms (SNPs) reportedly play an important role in determining metabolic risk among diverse population. Whether PPARγ-γ SNPs affect the clinical courses in ESRD patients is unknown. Methods. From a multicenter cohort, we identified 698 patients with prevalent ESRD between 2002 and 2003, and other 782 healthy subjects as control. Two PPARγ-γ SNPs, Pro12Ala (rs1801282) and C161T (rs3856806), were genotyped and their association with ESRD was examined. Both groups were prospectively followed until 2007, and the predictability of genotypes for the long-term survival of ESRD patients was analyzed. Results. After multivariable-adjusted regression, GG genotype of Pro12Ala was significantly more likely to associate with ESRD (P < 0.001) among patients with non-diabetes-related ESRD. Cox's proportional hazard regression showed that both Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM (Pro12Ala: GG versus other genotypes, hazard ratio [HR] <0.01; P < 0.001; for C161T, CC versus TT genotypes, HR 2.86; P < 0.001; CT versus TT genotypes, HR 1.93; P < 0.001). Conclusion. This is the first and largest study to evaluate PPARγ-γ SNPs in ESRD patients. Further mechanistic study is needed to elucidate the role of PPARγ-γ among ESRD patients. ? 2015 Chia-Ter Chao et al.
SDGs
Other Subjects
albumin; creatinine; hemoglobin; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor gamma; adult; albumin blood level; Article; chronic glomerulonephritis; controlled study; creatinine blood level; diabetic nephropathy; disease course; end stage renal disease; female; follow up; genetic association; genetic variability; genotype; hemoglobin blood level; human; kidney polycystic disease; long term survival; major clinical study; male; middle aged; mortality; prevalence; priority journal; prospective study; single nucleotide polymorphism; aged; case control study; chronic kidney failure; genetics; missense mutation; pathology; single nucleotide polymorphism; Aged; Aged; Case-Control Studies; Case-Control Studies; Diabetic Nephropathies; Diabetic Nephropathies; Female; Female; Humans; Humans; Kidney Failure, Chronic; Kidney Failure, Chronic; Male; Male; Middle Aged; Middle Aged; Mutation, Missense; Mutation, Missense; Polymorphism, Single Nucleotide; Polymorphism, Single Nucleotide; PPAR gamma; PPAR gamma
Type
journal article