https://scholars.lib.ntu.edu.tw/handle/123456789/479135
標題: | Synergistic effects of aerobic exercise and cognitive training on cognition, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline: Study protocol for a randomized controlled trial | 作者: | Yeh T.-T. Wu C.-Y. Hsieh Y.-W. Chang K.-C. Lee L.-C. Hung J.-W. KEH-CHUNG LIN Teng C.-H. Liao Y.-H. |
公開日期: | 2017 | 出版社: | BioMed Central Ltd. | 卷: | 18 | 期: | 1 | 起(迄)頁: | 405 | 來源出版物: | Trials | 摘要: | Background: Aerobic exercise and cognitive training have been effective in improving cognitive functions; however, whether the combination of these two can further enhance cognition and clinical outcomes in stroke survivors with cognitive decline remains unknown. This study aimed to determine the treatment effects of a sequential combination of aerobic exercise and cognitive training on cognitive function and clinical outcomes. Methods/design: Stroke survivors (n = 75) with cognitive decline will be recruited and randomly assigned to cognitive training, aerobic exercise, and sequential combination of aerobic exercise and cognitive training groups. All participants will receive training for 60 minutes per day, 3 days per week for 12 weeks. The aerobic exercise group will receive stationary bicycle training, the cognitive training group will receive cognitive-based training, and the sequential group will first receive 30 minutes of aerobic exercise, followed by 30 minutes of cognitive training. The outcome measures involve cognitive functions, physiological biomarkers, daily function and quality of life, physical functions, and social participation. Participants will be assessed before and immediately after the interventions, and 6 months after the interventions. Repeated measures of analysis of variance will be used to evaluate the changes in outcome measures at the three assessments. Discussion: This trial aims to explore the benefits of innovative intervention approaches to improve the cognitive function, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline. The findings will provide evidence to advance post-stroke cognitive rehabilitation. Trial registration: ClinicalTrials.gov, NCT02550990. Registered on 6 September 2015. ? 2017 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028538929&doi=10.1186%2fs13063-017-2153-7&partnerID=40&md5=355e96499df29be5938f206401093043 https://scholars.lib.ntu.edu.tw/handle/123456789/479135 |
ISSN: | 1745-6215 | DOI: | 10.1186/s13063-017-2153-7 | SDG/關鍵字: | adult; aerobic exercise; aged; Article; cerebrovascular accident; clinical effectiveness; clinical protocol; cognitive rehabilitation; cognitive therapy; controlled study; human; intervention study; major clinical study; mental deterioration; multicenter study; outcome assessment; physical capacity; quality of life; randomized controlled trial; single blind procedure; social participation; stroke rehabilitation; survivor; therapy effect; cerebrovascular accident; clinical trial; cognition; cognitive defect; convalescence; cycling; daily life activity; dementia assessment; disability; female; kinesiotherapy; male; methodology; middle aged; multimodality cancer therapy; pathophysiology; procedures; psychology; quality of life; Stroop test; Taiwan; time factor; treatment outcome; very elderly; walk test; young adult; Activities of Daily Living; Adult; Aged; Aged, 80 and over; Bicycling; Clinical Protocols; Cognition; Cognition Disorders; Cognitive Therapy; Combined Modality Therapy; Disability Evaluation; Exercise Therapy; Female; Humans; Male; Mental Status and Dementia Tests; Middle Aged; Quality of Life; Recovery of Function; Research Design; Single-Blind Method; Social Participation; Stroke; Stroop Test; Taiwan; Time Factors; Treatment Outcome; Walk Test; Young Adult |
顯示於: | 職能治療學系 |
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