https://scholars.lib.ntu.edu.tw/handle/123456789/479212
標題: | Constraint-induced movement therapy as a paradigm of translational research in neurorehabilitation: Reviews and prospects | 作者: | Huang W.-C. Chen Y.-J. CHUNG-LIANG CHIEN Kashima H. KEH-CHUNG LIN |
公開日期: | 2011 | 卷: | 3 | 期: | 1 | 起(迄)頁: | 48-60 | 來源出版物: | American Journal of Translational Research | 摘要: | There is an increasing awareness about the importance of translation from basic scientific findings into practical application for efficiently improving human health, especially in the pharmaceutical industry. In the field of neurorehabilitation, however, the bench-to-bedside process continues to be developing, and thus most of the therapeutic interventions have encountered barriers during exploration of evidence-based effectiveness. Despite this immaturity, constraint-induced movement therapy (CIT), a well-evidenced treatment evolved from research in nonhumanprimates, is suggested to be an ideal paradigm of translational research in the field of neurorehabilitation. This article reviews the evolvement of CIT with regards to its behavioral efficacy and neuroimaging evidence through the translation roadmap developed by the National Institutes of Health. We also discuss prospects for the application of combined interventions, such as stem cell therapy or pharmaceutical prescription, with appropriate screening of patients beforehand, as well as an efficient delivery mode after the treatment. To achieve such goals and consolidate evidenced- based neurorehabilitation, we provide a framework for applications into the translational research of other therapeutic interventions aside from CIT. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78650205893&partnerID=40&md5=d233bbb595d10412e3cba74833e3fa3c https://scholars.lib.ntu.edu.tw/handle/123456789/479212 |
ISSN: | 1943-8141 | SDG/關鍵字: | constraint induced therapy; evidence based medicine; human; medical research; movement therapy; nerve cell plasticity; neuroimaging; nonhuman; primate; review; stem cell transplantation |
顯示於: | 職能治療學系 |
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