https://scholars.lib.ntu.edu.tw/handle/123456789/479225
標題: | Constraint-induced therapy versus control intervention in patients with stroke: A functional magnetic resonance imaging study | 作者: | KEH-CHUNG LIN Chung H.-Y. Wu C.-Y. Liu H.-L. Hsieh Y.-W. Chen I.-H. Chen C.-L. Chuang L.-L. Liu J.-S. Wai Y.-Y. |
公開日期: | 2010 | 卷: | 89 | 期: | 3 | 起(迄)頁: | 177-185 | 來源出版物: | American Journal of Physical Medicine and Rehabilitation | 摘要: | Objective: This study compared the effects of a distributed form of constraint-induced therapy with control intervention in motor recovery and brain reorganization after stroke. Design: A two-group randomized controlled trial with pretreatment and posttreatment measures was conducted. Thirteen patients with stroke were randomly assigned to the distributed form of constraint-induced therapy (n = 5) or the control intervention group (n = 8). Outcome measures included the Fugl-Meyer Assessment, the Motor Activity Log, and functional magnetic resonance imaging examination. The number of activation voxels and laterality index were determined from the functional magnetic resonance imaging data for the study of brain reorganization. Results: The distributed form of constraint-induced therapy group exhibited significantly greater improvements in the Fugl-Meyer Assessment and Motor Activity Log than the control intervention group. The functional magnetic resonance imaging data showed that distributed form of constraint-induced therapy significantly increased activation in the contralesional hemisphere during movement of the affected and unaffected hand. The control intervention group showed a decrease in primary sensorimotor cortex activation of the ipsilesional hemisphere during movement of the affected hand. Conclusions: The preliminary findings indicate that brain adaptation may be modulated by specific rehabilitation practices, although generalization of the functional magnetic resonance imaging findings is limited by sample size. Further research is needed to identify the specific neural correlates of the behavioral gains achieved after rehabilitation therapies. Copyright ? 2010 by Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77649166432&doi=10.1097%2fPHM.0b013e3181cf1c78&partnerID=40&md5=a3945d56d83fc89772fd92569c5922b8 https://scholars.lib.ntu.edu.tw/handle/123456789/479225 |
ISSN: | 0894-9115 | DOI: | 10.1097/PHM.0b013e3181cf1c78 | SDG/關鍵字: | article; brain; clinical trial; controlled clinical trial; controlled study; daily life activity; disability; exercise; female; hemispheric dominance; human; image processing; male; middle aged; motor cortex; movement (physiology); multicenter study; nuclear magnetic resonance imaging; pathology; randomized controlled trial; somatosensory cortex; stroke; Activities of Daily Living; Brain; Disability Evaluation; Dominance, Cerebral; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex; Movement; Restraint, Physical; Somatosensory Cortex; Stroke |
顯示於: | 職能治療學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。