Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway
Journal
Journal of Experimental and Clinical Cancer Research
Journal Volume
36
Journal Issue
1
Pages
1-13
Date Issued
2017
Author(s)
Cheng H.-W.
Chen Y.-F.
Weng C.-W.
Chen H.-Y.
Chen J.J.W.
Abstract
In this study, we found that cancer cells can promote endothelial cell tube formation and survival, at least in part, through the PI3K/Akt signalling pathway and thus change the microenvironment to benefit tumour growth. The gene signatures from HUVECs are associated with the clinical outcome of NSCLC patients.
SDGs
Type
journal article