Rare presentation of endocrine pancreatic tumor: A case of diffuse glucagonoma without metastasis and necrolytic migratory erythema
Journal
Journal of the Formosan Medical Association
Journal Volume
104
Journal Issue
5
Pages
363-366
Date Issued
2005
Author(s)
Abstract
Glucagonoma is a very rare endocrine pancreatic tumor. At diagnosis, most glucagonomas are malignant and often metastatic. Suspicion of glucagonoma is based on characteristic presentations known as "glucagonoma syndrome". Glucagonoma is often found in the pancreatic body and/or tail and is usually large enough to be localized by computed tomography. We report a case of diffuse glucagonoma necrolytic migratory erythema (NME) in a 45-year-old man with mild diabetes mellitus, mild anemia, and weight loss over 1.5 years. Diffused enlarged pancreas was noted on abdominal ultrasonography incidentally during a routine health check-up. The levels of carcinoembryonic antigen and carbohydrate antigen 19-9 were within normal limits. No enlarged lymph node or extrapancreatic tumor mass was found by several imaging studies. Total pancreatectomy was performed, and the pathology revealed glucagon-producing islet cells and intrapancreatic vascular emboli of tumor cells. He died due to internal bleeding and sepsis after surgery. Presentation of diffuse malignant glucagonoma with tumor emboli but no metastasis or NME is unusual.
SDGs
Other Subjects
antidiabetic agent; CA 19-9 antigen; carcinoembryonic antigen; adult; anamnesis; article; bleeding; case report; computer assisted tomography; diabetes mellitus; erythema; glucagonoma; human; human tissue; laboratory test; male; metastasis; nuclear magnetic resonance imaging; pancreas resection; pancreas tumor; pancreaticoduodenectomy; sepsis; glucagonoma; middle aged; pancreas tumor; Glucagonoma; Humans; Male; Middle Aged; Pancreatectomy; Pancreatic Neoplasms
Type
journal article