|Title:||Prevalence and risk factors for colonization by extended-spectrum β-lactamase-producing or ST 131 escherichia coli among asymptomatic adults in community settings in Southern Taiwan||Authors:||Wu P.-C.
|Issue Date:||2019||Journal Volume:||12||Start page/Pages:||1063-1071||Source:||Infection and Drug Resistance||Abstract:||
Purpose: Fecal carriage of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is common in Asia, especially in China and Southeast Asia. There are no data about fecal carriage of ESBL-EC and mcr-1-positive E. coli in Taiwan, and few studies focusing on the risk factors of asymptomatic fecal carriage of epidemic ST131 E. coli have been published. Patients and methods: From healthy inhabitants attending health examinations at a medical center in southern Taiwan in 2017, we collected 724 stool samples, which were examined for ESBL-EC fecal carriage using chromogenic medium. ST131 and mcr1-positive E. coli were also investigated using multiplex PCR. Clinical data from all participating adults were collected to analyze the risk factors for fecal ESBL-EC or ST131 E. coli carriage. Results: The prevalence rate of asymptomatic ESBL-EC fecal carriage in adults was 1.9% (14/724). ST131 was found in 22 (3.0%) adults and mcr-1-positive E. coli was found in three (0.4%) adults. A multivariate analysis showed that the risk factors associated with ESBL-EC carriage were diabetes mellitus (adjusted odds ratio [aOR]: 5.5, 95% confidence interval [CI]: 1.3–22.7), a history of colonic polyps (aOR: 6.4, 95% CI: 1.6–24.9), and chronic renal insufficiency (aOR: 20.7, 95% CI: 1.4–305.7). Underlying cancer (aOR: 4.8, 95% CI: 1.0–22.5) and stroke (aOR: 18.0, 95% CI: 1.6–207.5) were associated with ST131 E. coli fecal carriage. In our cohort, travel to Asian countries and food habit were not associated with ST131 or ESBL-EC fecal carriage. Conclusions: The ESBL-EC or ST131 E. coli fecal carriage rate is low among asymptomatic adults in Taiwan. Certain underlying medical conditions were associated with their fecal carriage. ? 2019 Wu et al.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/479698||ISSN:||1178-6973||DOI:||10.2147/IDR.S201086||SDG/Keyword:||adult; Article; asymptomatic disease; bacterial colonization; bacterial gene; bacterial strain; bacterium identification; cerebrovascular accident; chronic kidney failure; cohort analysis; colon polyp; community assessment; comorbidity; diabetes mellitus; epidemic; Escherichia coli infection; extended spectrum beta lactamase producing Escherichia coli; feces analysis; female; human; male; malignant neoplasm; mcr 1 gene; medical history; multivariate analysis; prevalence; risk factor; Taiwan
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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