|Title:||Breakthrough Streptococcus pneumoniae type 6B infection after adrenocorticotropic hormone therapy in a child vaccinated with pneumococcal conjugate vaccine||Authors:||Lee M.-H.
|Issue Date:||2013||Journal Volume:||112||Journal Issue:||4||Start page/Pages:||230-232||Source:||Journal of the Formosan Medical Association||Abstract:||
Despite proven good efficacy of pneumococcal conjugated vaccine in preventing invasive pneumococcal disease, breakthrough infections remain a noticeable problem with significant morbidity and mortality, especially in selected high-risk groups. We present a 2-year-old girl with infantile spasm, who was treated with antiepileptic drugs and adrenocorticotropic hormone (ACTH). Vaccination with three doses 7-valent pneumococcal conjugate vaccine had been completed one month before ACTH therapy. Two months after ACTH therapy, she suffered from fever, cough, and decreased activity. Streptococcus pneumoniae, serotype 6B, was detected in blood culture. Vaccine failure could be possibly due to ACTH therapy. ? 2012.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/479914||ISSN:||0929-6646||DOI:||10.1016/j.jfma.2012.10.011||SDG/Keyword:||ampicillin; C reactive protein; corticotropin; hemoglobin; lamotrigine; oxcarbazepine; penicillin G; phenobarbital; Pneumococcus vaccine; sultamicillin; tetracosactide; vigabatrin; antibiotic therapy; Apgar score; article; birth weight; blood culture; brain atrophy; bronchopneumonia; case report; child; common cold; coughing; drug dose reduction; female; fever; gestational age; hemoglobin blood level; human; hyperemia; infantile spasm; leukocyte count; minimum inhibitory concentration; nervous system development; pneumococcal infection; preschool child; protein blood level; serotype; Streptococcus pneumoniae; thorax radiography; throat culture; thrombocyte count; vaccination; vaccine failure; virus isolation; Adrenocorticotropic Hormone; Child, Preschool; Female; Humans; Immunocompromised Host; Pneumococcal Infections; Pneumococcal Vaccines; Vaccines, Conjugate
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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