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  4. Lower prevalence of tuberculosis infection in BCG vaccinees: A cross-sectional study in adult prison inmates
 
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Lower prevalence of tuberculosis infection in BCG vaccinees: A cross-sectional study in adult prison inmates

Journal
Thorax
Journal Volume
68
Journal Issue
3
Pages
263-268
Date Issued
2013
Author(s)
Chan P.-C.
Yang C.-H.
LUAN-YIN CHANG  
Wang K.-F.
Kuo Y.-C.
Lin C.-J.
Lee S.-W.
PO-REN HSUEH  
CHI-TAI FANG  
LI-MIN HUANG  
DOI
10.1136/thoraxjnl-2012-202208
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/479924
Abstract
Objectives: To address whether the effect of BCG vaccination against tuberculosis (TB) infection lasts to adulthood. Methods: A cross-sectional study on the prevalence of latent TB infection (LTBI) among HIV-negative men, using QuantiFERON-TB Gold In-tube (QFT-IT), was conducted at a prison in northern Taiwan with >3000 inmates. A QFT-IT ?0.35 IU/ml was defined as LTBI. A QFT-IT ?0.7 IU/ml was defined as recent LTBI. The association between the number of BCG scars and LTBI stratified by age was analysed. The study procedure was approved by the institutional review board, and all participants gave written informed consent before receiving screening tests. Results: Among the 2385 participants, 25% had a QFT-IT ?0.35 IU/ml. Increasing LTBI (14%, 32% and 50%) was observed with increased age (18-34 years, 35-54 years and ?55 years) (p<0.001 by the Cochran-Armitage Trend Test). The number of BCG scars were found to be inversely correlated with QFT-IT results for both LTBI and recent LTBI in all three age groups (p<0.001 by Cochran-Mantel-Haenszel statistics). Conclusions: Our results suggest that BCG vaccine seems to have a protective effect in adults decades after vaccination according to the number of recent infections (QFT-IT ?0.7 IU/ml). This finding has important implications for national policy of BCG vaccination. Further prospective cohort studies on the protective effect of BCG vaccination against TB infection in adults are warranted.
SDGs

[SDGs]SDG3

Other Subjects
BCG vaccine; adult; adulthood; age distribution; aged; article; BCG vaccination; cross-sectional study; health care policy; human; interferon gamma release assay; latent tuberculosis; major clinical study; prevalence; priority journal; prison; prisoner; protection; reference value; scar; screening test; Taiwan
Type
journal article

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