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  4. Association between incidence of candidaemia and consumption of antifungal agents at a medical centre in Taiwan
 
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Association between incidence of candidaemia and consumption of antifungal agents at a medical centre in Taiwan

Journal
International Journal of Antimicrobial Agents
Journal Volume
40
Journal Issue
4
Pages
349-353
Date Issued
2012
Author(s)
Lai C.-C.
Chu C.-C.
Wang C.-Y.
Tsai H.-Y.
ARISTINE CHENG  
Lee Y.-C.
YU-TSUNG HUANG  
Liao C.-H.
PO-REN HSUEH  
DOI
10.1016/j.ijantimicag.2012.05.024
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/479939
Abstract
This study investigated the correlations between consumption of antifungal agents and species distribution in candidaemia. The incidence of patients with community-acquired candidaemia (CAC) (per 1000 admissions) and healthcare-associated candidaemia (HCAC) (per 1000 admissions) as well as data on annual consumption [defined daily doses (DDD)/1000 patient-days] of various antifungal agents at a medical centre in Taiwan from 2000 to 2010 were evaluated. A total of 2682 episodes of candidaemia were identified, including 2468 HCAC (92.0%) and 214 CAC (8.0%). The most prevalent species was Candida albicans (53.3%), followed by Candida tropicalis (20.5%), Candida glabrata (15.4%), Candida parapsilosis (14.1%), Candida guilliermondii (1.7%) and Candida krusei (1.5%). The overall incidence of candidaemia remained stable, whereas that of candidaemia due to C. parapsilosis and C. guilliermondii decreased significantly with time. Significant negative correlations were found between the use of echinocandins and voriconazole and the incidence of C. parapsilosis candidaemia and between the use of caspofungin and the incidence of C. guilliermondii candidaemia. In contrast, there were significant positive correlations between the use of echinocandins and the incidence of C. tropicalis candidaemia, the use of azoles and the incidence of C. glabrata and non-albicans Candida candidaemia, and the use of itraconazole and the incidence of C. parapsilosis and C. guilliermondii candidaemia. Increased use of fluconazole was associated with an increased incidence of HCAC due to non-albicans Candida spp. In conclusion, the impact of consumption of antifungal agents on the incidence of candidaemia caused by different Candida spp. varies and warrants further studies to confirm these findings. ? 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
SDGs

[SDGs]SDG3

Other Subjects
amphotericin B; antifungal agent; caspofungin; echinocandin; fluconazole; itraconazole; micafungin; pyrrole derivative; voriconazole; article; Candida albicans; Candida glabrata; Candida parapsilosis; Candida tropicalis; candidemia; communicable disease; community acquired candidemia; drug use; healthcare associated candidemia; healthcare associated infection; human; incidence; Pichia guilliermondii; priority journal; species distribution; Taiwan; Academic Medical Centers; Antifungal Agents; Azoles; Candida; Candidemia; Community-Acquired Infections; Drug Utilization; Echinocandins; Humans; Incidence; Taiwan
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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