https://scholars.lib.ntu.edu.tw/handle/123456789/479939
標題: | Association between incidence of candidaemia and consumption of antifungal agents at a medical centre in Taiwan | 作者: | Lai C.-C. Chu C.-C. Wang C.-Y. Tsai H.-Y. ARISTINE CHENG Lee Y.-C. YU-TSUNG HUANG Liao C.-H. PO-REN HSUEH |
公開日期: | 2012 | 卷: | 40 | 期: | 4 | 起(迄)頁: | 349-353 | 來源出版物: | International Journal of Antimicrobial Agents | 摘要: | This study investigated the correlations between consumption of antifungal agents and species distribution in candidaemia. The incidence of patients with community-acquired candidaemia (CAC) (per 1000 admissions) and healthcare-associated candidaemia (HCAC) (per 1000 admissions) as well as data on annual consumption [defined daily doses (DDD)/1000 patient-days] of various antifungal agents at a medical centre in Taiwan from 2000 to 2010 were evaluated. A total of 2682 episodes of candidaemia were identified, including 2468 HCAC (92.0%) and 214 CAC (8.0%). The most prevalent species was Candida albicans (53.3%), followed by Candida tropicalis (20.5%), Candida glabrata (15.4%), Candida parapsilosis (14.1%), Candida guilliermondii (1.7%) and Candida krusei (1.5%). The overall incidence of candidaemia remained stable, whereas that of candidaemia due to C. parapsilosis and C. guilliermondii decreased significantly with time. Significant negative correlations were found between the use of echinocandins and voriconazole and the incidence of C. parapsilosis candidaemia and between the use of caspofungin and the incidence of C. guilliermondii candidaemia. In contrast, there were significant positive correlations between the use of echinocandins and the incidence of C. tropicalis candidaemia, the use of azoles and the incidence of C. glabrata and non-albicans Candida candidaemia, and the use of itraconazole and the incidence of C. parapsilosis and C. guilliermondii candidaemia. Increased use of fluconazole was associated with an increased incidence of HCAC due to non-albicans Candida spp. In conclusion, the impact of consumption of antifungal agents on the incidence of candidaemia caused by different Candida spp. varies and warrants further studies to confirm these findings. ? 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/479939 | ISSN: | 0924-8579 | DOI: | 10.1016/j.ijantimicag.2012.05.024 | SDG/關鍵字: | amphotericin B; antifungal agent; caspofungin; echinocandin; fluconazole; itraconazole; micafungin; pyrrole derivative; voriconazole; article; Candida albicans; Candida glabrata; Candida parapsilosis; Candida tropicalis; candidemia; communicable disease; community acquired candidemia; drug use; healthcare associated candidemia; healthcare associated infection; human; incidence; Pichia guilliermondii; priority journal; species distribution; Taiwan; Academic Medical Centers; Antifungal Agents; Azoles; Candida; Candidemia; Community-Acquired Infections; Drug Utilization; Echinocandins; Humans; Incidence; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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