Disseminated candidemia refractory to caspofungin therapy in an infant with extremely low birth weight
Journal
Journal of the Formosan Medical Association
Journal Volume
111
Journal Issue
1
Pages
46-50
Date Issued
2012
Abstract
Systemic fungal infections have high morbidity and mortality rates in neonates, especially neonates with an extremely low birth weight (ELBW). Here, we describe a 21-day-old ELBW female infant with an amphotericin B-unresponsive congenital Candida albicans infection that was treated with caspofungin. Blood sterilization was performed during the first episode, but a second episode of candidemia occurred after the discontinuation of caspofungin. Blood sterilization was again performed during the second round of caspofungin treatment, but fungal endocarditis and renal fungal balls still developed during the second episode. Caspofungin can be considered for invasive candidiasis in premature infants, especially in life-threatening situations. As for the focal lesions, more aggressive treatments other than just parenteral antibiotics should be considered. The literature regarding caspofungin therapy for neonatal candidiasis is also reviewed. ? 2012.
SDGs
Other Subjects
amphotericin B; ampicillin; C reactive protein; caspofungin; ceftazidime; gentamicin; vancomycin; acute kidney failure; article; artificial ventilation; Candida albicans; candidemia; case report; cholestasis; echocardiography; echography; erythema; extremely low birth weight; female; follow up; fungal endocarditis; fungus ball; human; hyperkalemia; hypotension; infant; infant disease; intubation; invasive candidiasis; leukocyte count; minimum inhibitory concentration; mortality; multiple organ failure; neutrophil count; papule; pneumothorax; premature fetus membrane rupture; recurrent disease; relapse; respiratory distress; scleroderma; skin exfoliation; thrombocyte count; thrombocyte transfusion; thrombocytopenia; Antifungal Agents; Candida albicans; Candidemia; Echinocandins; Fatal Outcome; Female; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn
Type
journal article