|Title:||Combination antifungal therapy for disseminated fusariosis in immunocompromised patients: A case report and literature review||Authors:||Liu J.-Y.
|Issue Date:||2011||Journal Volume:||49||Journal Issue:||8||Start page/Pages:||872-878||Source:||Medical Mycology||Abstract:||
Fusarium species are the second leading cause of disseminated mold infections in immunocompromised patients. The high mortality caused by such infections is attributed to the high resistance of Fusarium species to current antifungal agents. We report the first case of disseminated fusariosis after the use of alemtuzumab, an anti-CD52 monoclonal antibody, in a patient who presented with striking cutaneous and oral cavity lesions. Case reports of combination antifungal therapy for disseminated fusariosis in immunocompromised patients were reviewed. Among 19 published cases in the last 10 years plus this patient, the patients in 14 cases (70%) responded positively to combination antifungal therapy. A clinical response was achieved in seven cases before resolution of neutropenia. ? 2011 ISHAM.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/480006||ISSN:||1369-3786||DOI:||10.3109/13693786.2011.567304||SDG/Keyword:||alemtuzumab; amphotericin B deoxycholate; cilastatin plus imipenem; cytarabine; etoposide; fluconazole; gemcitabine; mitoxantrone; vancomycin; voriconazole; adult; antibiotic therapy; antifungal susceptibility; case report; cutaneous T cell lymphoma; drug substitution; drug withdrawal; febrile neutropenia; fusariosis; Fusarium solani; human; human cell; human tissue; immunocompromised patient; immunohistochemistry; leukemia; loading drug dose; lymphoid cell; male; minimum inhibitory concentration; monotherapy; mouth lesion; neutropenia; nonhuman; odynophagia; review; skin biopsy; skin defect; skin necrosis; tumor; Adult; Amphotericin B; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antineoplastic Agents; Combined Modality Therapy; Deoxycholic Acid; Drug Combinations; Drug Therapy, Combination; Fever; Fusariosis; Fusarium; Granulocytes; Humans; Immunocompromised Host; Leukocyte Transfusion; Lymphoma, T-Cell, Cutaneous; Male; Microbial Sensitivity Tests; Neutropenia; Pyrimidines; Skin Neoplasms; Triazoles; Fusarium
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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