Correlation between antimicrobial consumption and resistance among Staphylococcus aureus and enterococci causing healthcare-associated infections at a university hospital in Taiwan from 2000 to 2009
Journal
European Journal of Clinical Microbiology and Infectious Diseases
Journal Volume
30
Journal Issue
2
Pages
265-271
Date Issued
2011
Author(s)
Abstract
This study investigated the correlation between antibiotic consumption and resistance among Staphylococcus aureus and enterococci causing healthcare-associated infections at a university hospital in Taiwan from 2000 to 2009. Overall, the trend of total consumption (defined daily dose [DDD] per 1,000 patient-days) of glycopeptides, including vancomycin and teicoplanin, significantly increased during 2000 to 2003 and remained stable during 2004-2009. Vancomycin consumption significantly increased during 2003 and decreased after 2004. A significant decrease in the resistance rate with time was found for oxacillin- and gentamicin-resistant S. aureus. In contrast, the rates of vancomycin- and teicoplanin-resistant enterocci increased significantly. A significant correlation was found between the increased use of extended-spectrum cephalosporins, β-lactam-β-lactamase inhibitor combinations, carbapenems and the decreased prevalence of methicillin-resistant S. aureus (MRSA). In contrast, the increased use of teicoplanin, extended-spectrum cephalosporins, β-lactam-β-lactamase inhibitor combinations, and carbapenems was correlated with the increased prevalence of vancomycin-resistant enterococci (VRE). In conclusion, this 10-year study in a single institution identified different correlations between the prescription of antibiotics and the resistance rates of MRSA and VRE. Strict implementation of infection control policy based on these correlates would be helpful in decreasing the presence of these multidrug-resistant pathogens in hospitals. ? 2010 Springer-Verlag.
SDGs
Other Subjects
amikacin; aminoglycoside antibiotic agent; beta lactam antibiotic; beta lactamase inhibitor; carbapenem derivative; cefepime; cefotaxime; cefpirome; ceftazidime; ceftriaxone; cephalosporin derivative; ciprofloxacin; ertapenem; fusidic acid; gentamicin; imipenem; levofloxacin; linezolid; meropenem; oxacillin; piperacillin plus tazobactam; polypeptide antibiotic agent; quinoline derived antiinfective agent; teicoplanin; timentin; vancomycin; antibiotic resistance; article; controlled study; drug use; Enterococcus; Enterococcus faecalis; hospital infection; human; major clinical study; methicillin resistant Staphylococcus aureus; prescription; priority journal; Staphylococcus aureus; Taiwan; trend study; university hospital; vancomycin resistant Enterococcus; Anti-Bacterial Agents; beta-Lactams; Cross Infection; Drug Resistance, Bacterial; Drug Utilization; Enterococcus; Glycopeptides; Gram-Positive Bacterial Infections; Humans; Staphylococcus aureus; Taiwan; Teicoplanin; Vancomycin
Type
journal article