https://scholars.lib.ntu.edu.tw/handle/123456789/480097
標題: | Enzyme-linked immunospot assay for interferon-gamma to support the diagnosis of tuberculosis in diabetic patients | 作者: | Tan C.K. Lai C.-C. Chen H.W. Liao C.-H. Chou C.-H. YU-TSUNG HUANG WEI-SHIUNG YANG CHONG-JEN YU PO-REN HSUEH |
公開日期: | 2010 | 卷: | 42 | 期: | 10 | 起(迄)頁: | 752-756 | 來源出版物: | Scandinavian Journal of Infectious Diseases | 摘要: | The aim of this study was to evaluate the support to tuberculosis diagnosis of a new immunological tool, an enzyme-linked immunospot (ELISPOT) assay for interferon-γ, in diabetic patients. From March 2007 to January 2008, diabetic patients with suspected pulmonary tuberculosis were enrolled in a tertiary care hospital. Data on clinical characteristics of the patients and conventional laboratory results were collected and blood samples were obtained for ELISPOT assay (T SPOT-TB; Oxford Immunotec Ltd, Oxford, UK). A total of 84 patients with suspected pulmonary tuberculosis were recruited. Fifty-one (60.7%) of these patients were considered to have pulmonary tuberculosis, including 42 (50%) with confirmed tuberculosis and 9 (10.7%) with probable tuberculosis. The overall (confirmed and probable tuberculosis) sensitivity, specificity, positive predictive value and negative predictive value of the ELISPOT assay were 84.3%, 66.7%, 79.6%, and 73.3%, respectively. The negative predictive value of the ELISPOT assay was significantly higher in patients with adequate glycaemic control (90% vs 56.3%). In conclusion, the ELISPOT assay can provide useful support in diagnosing pulmonary tuberculosis in diabetic patients, especially those with adequate glycaemic control. ? 2010 Informa Healthcare. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480097 | ISSN: | 0036-5548 | DOI: | 10.3109/00365548.2010.490237 | SDG/關鍵字: | gamma interferon; adult; aged; article; blood sampling; clinical study; controlled study; diabetic patient; diagnostic accuracy; enzyme linked immunospot assay; female; glycemic control; human; information processing; lung tuberculosis; major clinical study; male; predictor variable; sensitivity and specificity; tertiary health care; Aged; Diabetes Complications; Enzyme-Linked Immunospot Assay; Female; Humans; Interferon-gamma; Male; Middle Aged; Mycobacterium tuberculosis; Predictive Value of Tests; Sensitivity and Specificity; Tuberculosis, Pulmonary |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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