https://scholars.lib.ntu.edu.tw/handle/123456789/480248
標題: | Comparative bactericidal activities of daptomycin, glycopeptides, linezolid and tigecycline against blood isolates of Gram-positive bacteria in Taiwan | 作者: | YU-TSUNG HUANG Liao C.-H. LEE-JENE TENG PO-REN HSUEH |
公開日期: | 2008 | 卷: | 14 | 期: | 2 | 起(迄)頁: | 124-129 | 來源出版物: | Clinical Microbiology and Infection | 摘要: | In-vitro MICs and minimum bactericidal concentrations (MBCs) of daptomycin, linezolid, tigecycline, vancomycin and teicoplanin against Gram-positive bacteria were determined using the broth microdilution method for ten blood isolates each of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S.aureus (MRSA), including two vancomycin-intermediate S.aureus (VISA), vancomycin-resistant Enterococcus faecium and Enterococcusfaecalis. One strain of VISA was tested in a time-kill synergism assay of daptomycin combined with oxacillin, imipenem, rifampicin and isepamicin. Daptomycin showed excellent in-vitro bactericidal activity against all the isolates tested, with no tolerance or synergism effects when combined with other agents, except with rifampicin against VISA. Vancomycin had better bactericidal activity against MRSA and MSSA than did teicoplanin. Linezolid had the poorest bactericidal activity against the isolates tested, with 100% tolerance by the MSSA and VRE isolates, and 80% tolerance by the MRSA isolates. Tolerance towards tigecycline was exhibited by 40% of the MRSA isolates, 100% of the MSSA and vancomycin-resistant E.faecalis isolates, and 90% of the vancomycin-resistant E.faecium isolates. ? 2007 The Authors Journal Compilation ? 2007 European Society of Clinical Microbiology and Infectious Diseases. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480248 | ISSN: | 1198-743X | DOI: | 10.1111/j.1469-0691.2007.01888.x | SDG/關鍵字: | antiinfective agent; cilastatin plus imipenem; daptomycin; glycopeptide; imipenem; isepamicin; linezolid; oxacillin; rifampicin; teicoplanin; tigecycline; vancomycin; antibiotic sensitivity; article; bacterial strain; bactericidal activity; bacterium isolation; drug efficacy; Gram positive bacterium; in vitro study; minimum inhibitory concentration; nonhuman; priority journal; Taiwan; Enterococcus faecium; methicillin resistant Staphylococcus aureus; Posibacteria; Staphylococcus aureus |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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