https://scholars.lib.ntu.edu.tw/handle/123456789/480262
標題: | Preferential induction of transforming growth factor-β production in gastric epithelial cells and monocytes by Helicobacter pylori soluble proteins | 作者: | MING-SHIANG WU JAW-TOWN LIN PING-NING HSU Ching-Yi Lin Yuan-Ting Hsieh Yi-Han Chiu PO-REN HSUEH Kuang-Wen Liao |
公開日期: | 1-十一月-2007 | 卷: | 196 | 期: | 9 | 起(迄)頁: | 1386-1393 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Background. The cytokines induced by Helicobacter pylori, as well as the intricate balance of proinflammatory and anti-inflammatory cytokines, are relevant to the outcomes of H. pylori infection. Transforming growth factor (TGF)-β and interleukin (IL)-10 are 2 vital anti-inflammatory cytokines that regulate mucosal immunity in various inflammatory and infectious diseases. Methods. To elucidate whether host-bacteria interaction can influence TGF-β and IL-10 production, we investigated the expression of TGF-β and IL-10 in various mammalian cell lines preincubated with H. pylori and other enteric bacteria. Results. The amount of TGF-β protein, but not IL-10, was significantly increased after stimulation with H. pylori, but other enteric bacteria did not induce TGF-β production. Different H. pylori strains isolated from patients with gastritis, peptic ulcer, gastric cancer and strains with cagA or vacA isogenic mutations showed similar effects on TGF-β induction, indicating that this effect was a constitutional characteristic of H. pylori and independent of cagA and vacA status. Conclusion. The results imply the presence of a protein factor (termed "TGF-β-inducing protein") that induces production of TGF-β. In view of the multiple effects of TGF-β, we conclude the TGF-β-inducing protein of H. pylori might mediate the immune response and contribute to the pathogenesis of H. pylori infection. ? 2007 by the Infectious Diseases Society of America. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480262 https://pubmed.ncbi.nlm.nih.gov/17922404/ |
ISSN: | 0022-1899 | DOI: | 10.1086/522520 | SDG/關鍵字: | bacterial protein; interleukin 10; transforming growth factor beta; bacterial antigen; bacterial protein; cagA protein, Helicobacter pylori; interleukin 10; transforming growth factor beta; unclassified drug; VacA protein, Helicobacter pylori; article; bacterium isolation; controlled study; cytokine production; duodenum ulcer; Enterobacteriaceae; gastritis; Helicobacter infection; Helicobacter pylori; human; human cell; major clinical study; monocyte; mutational analysis; priority journal; protein expression; stomach cancer; stomach epithelium; stomach ulcer; biosynthesis; chemistry; cytology; epithelium cell; genetics; Helicobacter pylori; metabolism; monocyte; stomach; tumor cell line; Antigens, Bacterial; Bacterial Proteins; Cell Line, Tumor; Epithelial Cells; Helicobacter pylori; Humans; Interleukin-10; Monocytes; Stomach; Transforming Growth Factor beta |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。