https://scholars.lib.ntu.edu.tw/handle/123456789/480483
標題: | Pulmonary tuberculosis in allogeneic hematopoietic stem cell transplantation | 作者: | SHIH-CHI KU JIH-LUH TANG PO-REN HSUEH KWEN-TAY LUH CHONG-JEN YU PAN-CHYR YANG |
公開日期: | 2001 | 卷: | 27 | 期: | 12 | 起(迄)頁: | 1293-1297 | 來源出版物: | Bone Marrow Transplantation | 摘要: | Pulmonary tuberculosis (TB) is an endemic infectious disease in Taiwan. A retrospective study was conducted to define clinical manifestations and outcomes of patients with pulmonary TB among hematopoietic stem cell transplantation (HSCT) recipients. We identified eight out of 350 HSCT recipients as having pulmonary TB over a 6-year period. The relative risk of having pulmonary TB after HSCT was 13.1-fold higher than in the general population. There was a trend toward increased risk of having pulmonary TB in allogeneic HSCT as compared to autologous HSCT (4.8± 1.8% vs 0, P = 0.067). All the eight patients with pulmonary TB received allogeneic HSCT and most (seven of eight patients) developed the infection during treatment for GVHD. Computed tomography of the chest was normal in one patient, with the rest showing either interstitial (two patients) or alveolar infiltrates (five patients) at the onset of pulmonary TB. The four fatal cases had an obviously shorter duration between HSCT and onset of infection. Our data suggest that pulmonary TB in HSCT recipients is not uncommon in this endemic area. Therefore, an effective strategy of prophylactic treatment for candidates and recipients of allogeneic HSCT, who may have latent pulmonary TB infection, must be developed. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480483 | ISSN: | 0268-3369 | DOI: | 10.1038/sj.bmt.1703092 | SDG/關鍵字: | amikacin; ciprofloxacin; cyclophosphamide; cyclosporin; cyclosporin A; cytarabine; ethambutol; isoniazid; methotrexate; methylprednisolone; ofloxacin; prednisolone; pyrazinamide; rifampicin; streptomycin; acute disease; adult; allograft; article; autotransplantation; child; chronic disease; clinical article; clinical feature; computer assisted tomography; controlled study; endemic disease; fatality; female; graft versus host reaction; hematopoietic stem cell transplantation; human; infection risk; lung alveolus; lung infiltrate; lung interstitium; lung tuberculosis; male; outcomes research; population; priority journal; recipient; retrospective study; Taiwan; whole body radiation; Adult; Child; Female; Hematopoietic Stem Cell Transplantation; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Risk Factors; Taiwan; Tomography, X-Ray Computed; Transplantation, Homologous; Treatment Outcome; Tuberculosis, Pulmonary |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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