https://scholars.lib.ntu.edu.tw/handle/123456789/480845
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | ZEI-SHUNG HUANG | en_US |
dc.contributor.author | SHYH-CHYI LO | en_US |
dc.contributor.author | WOEI TSAY | en_US |
dc.contributor.author | Hsu K.-L. | en_US |
dc.contributor.author | FU-TIEN CHIANG | en_US |
dc.creator | Huang Z.-S.;Shyh-Chyi Lo;Tsay W.;Hsu K.-L.;Chiang F.-T. | - |
dc.date.accessioned | 2020-03-30T03:55:56Z | - |
dc.date.available | 2020-03-30T03:55:56Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/480845 | - |
dc.description.abstract | Background/Purpose: A higher total leukocyte count is a predictor of all-cause mortality and cardiovascular morbidity. The currently used reference range for peripheral total leukocyte count is wide (4.5- 11.0 × 109/L) and is associated with a low sensitivity in identifying non-infectious chronic diseases. We attempt to revise it based on a normal serum C-reactive protein (CRP) level. Methods: Study subjects were participants in a health check program at our hospital between 2000 and 2002. Those whose leukocyte analysis had been checked with the Sysmex Cell Counter NE-9000 were enrolled. Results: Significantly positive relationships between CRP level and total leukocyte count, neutrophil percentage, and monocyte percentage were found in all subjects (n = 14,114; p < 0.0001). In contrast, CRP level had a significantly inverse correlation with lymphocyte percentage (p < 0.0001). A proposed new reference range for total leukocyte count was estimated based on the data in the normal CRP level group (CRP < 0. 1 mg/dL; n = 4839). To rest on the essence of statistics that the range of [mean ± 2 standard deviations] contains approximately the middle 95% of observations in a sampled population, a new reference range for total leukocyte count was accordingly estimated to be 3.11-8.83 × 109/L. Conclusion: In view of the abundant evidence showing that a higher peripheral total leukocyte count is harmful to health, a down-correction of its upper reference range from the currently used 11.0 × 109/L to the proposed 8.83 × 109/L, based on a normal CRP level, should allow more abnormal health conditions to be identified and promote the usefulness of peripheral leukocyte analysis. ? 2007 Elsevier & Formosan Medical Association. | - |
dc.relation.ispartof | Journal of the Formosan Medical Association | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | C reactive protein; adolescent; adult; aged; article; controlled study; female; human; leukocyte count; leukocyte differential count; lymphocyte count; major clinical study; male; monocyte; neutrophil count; protein blood level; reference value | - |
dc.title | Revision in reference ranges of peripheral total leukocyte count and diffential leukocyte percentages based on a normal serum C-reactive protein level | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S0929-6646(08)60017-0 | - |
dc.identifier.pmid | 17711793 | - |
dc.identifier.scopus | 2-s2.0-34548472664 | - |
dc.relation.pages | 608-616 | - |
dc.relation.journalvolume | 106 | - |
dc.relation.journalissue | 8 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-4670-2513 | - |
crisitem.author.orcid | 0000-0002-6745-5953 | - |
crisitem.author.orcid | 0000-0001-6244-3868 | - |
crisitem.author.orcid | 0000-0003-4936-8968 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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