Metastasizing Granular Cell Type Ameloblastoma with Intracranial Perineural Spread along the Abducens Nerve
Journal
Journal of Cancer Research and Practice
Journal Volume
2
Journal Issue
3
Pages
261-269
Date Issued
2015
Author(s)
CHEN-HAO LI
PEI-HSIN HUANG
YA-FANG CHEN
HUI-CHUAN CHEN
SHIN-YI HUANG
SHENG-JEAN HUANG
Abstract
Ameloblastomas are benign but locally invasive odontogenic epithelial tumors. They have a high tendency to recur, but a low incidence of metastasis. This is the first reported case presenting a perineural spread of metastasis in ameloblastoma. This is the case of a 74-year-old man with left mandibular granular cell type ameloblastoma diagnosed in 1978. Local recurrence occurred 26 years after tumor excision, and he again received surgical treatment. Distant metastasis with intracranial perineural spread along the sixth cranial nerve occurred 9 years after the second operation. The diagnosis was confirmed by excisional biopsy of the intracranial lesion and a needle biopsy of the left mandibular tumor. Only 5 patients have been previously reported with metastasized granular cell type ameloblastoma. We herein have presented a characterization of granular cell type ameloblastomas and a possible mechanism for perineural spread.
SDGs
Type
journal article