Epithelial-myoepithelial carcinoma of the salivary gland harboring HRAS codon 61 mutations with lung metastasis
Journal
International Journal of Surgical Pathology
Journal Volume
24
Journal Issue
3
Pages
227-231
Date Issued
2015
Author(s)
Abstract
Here, we report a case involving a 43-year-old man diagnosed with Burkitt lymphoma in 2007. At the same time, 2 small lung nodules were incidentally found; however, they presented no indication of growth throughout the follow-up period. However, a 1.5-cm nodule located in the right parotid gland in 2010 gradually increased in size to 2.8 cm by 2012. A parotidectomy revealed an epithelial-myoepithelial carcinoma, characterized by biphasic tubular structures and solid areas presenting myoepithelial overgrowth. Tumor necrosis and regional lymph node invasion were also observed. During clinical follow-up in 2013, a new 1.3-cm nodule was identified in the left lower lobe of the lung, which enlarged to 3 cm by 2014. Wedge resection of the left lung nodules revealed round nodes with well-defined borders. Histologically, these lung tumors predominantly comprised spindle-shaped myoepithelial cells with occasional tubular structures. Numerous cleft-like spaces lined by entrapped TTF-1-immunoreactive pneumocytes were observed inside the nodules. The lung nodules were characterized by a morphology similar to that of the parotid cancer. Epithelial-myoepithelial carcinoma with lung metastasis was confirmed by molecular testing, which revealed identical HRAS codon 61 (Q61K) mutations in the primary parotid tumor as well as in the lung metastases. ? The Author(s) 2015.
SDGs
Other Subjects
thyroid transcription factor 1; codon; HRAS protein, human; protein p21; adult; Article; Burkitt lymphoma; cancer diagnosis; case report; codon; computer assisted tomography; epithelial myoepithelial carcinoma of the salivary gland; follow up; gene mutation; hemicolectomy; histopathology; human; human tissue; immunoreactivity; incidental finding; intestine lymphoma; lung alveolus cell; lung lobe; lung metastasis; lung nodule; lymph node metastasis; male; molecular diagnosis; myoepithelium cell; oncogene H ras; parotid gland; parotid gland tumor; parotidectomy; priority journal; salivary gland carcinoma; tumor growth; tumor necrosis; wedge resection; Burkitt lymphoma; carcinoma; genetics; lung tumor; mutation; myoepithelioma; parotid gland tumor; pathology; reverse transcription polymerase chain reaction; second cancer; secondary; Adult; Burkitt Lymphoma; Carcinoma; Codon; Humans; Lung Neoplasms; Male; Mutation; Myoepithelioma; Neoplasms, Second Primary; Parotid Neoplasms; Proto-Oncogene Proteins p21(ras); Reverse Transcriptase Polymerase Chain Reaction
Publisher
SAGE Publications Inc.
Type
journal article