Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Thymectomy for patients with myasthenia gravis: Factors influencing the outcome
 
  • Details

Thymectomy for patients with myasthenia gravis: Factors influencing the outcome

Journal
Journal of Surgical Association Republic of China
Journal Volume
30
Journal Issue
5
Pages
329-337
Date Issued
1997
Author(s)
Luh S.-P.
YIH-LEONG CHANG  
JIN-SHING CHEN  
Huang C.-C.
Lee Y.-C.
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031430071&partnerID=40&md5=bd6adc5c866e971b073dffb15ac8ed3b
https://scholars.lib.ntu.edu.tw/handle/123456789/481166
Abstract
In the present study, the role of thymectomy in the treatment of myasthenia gravis (MG) has been analysed for 70 simple or thymomatous MG patients that underwent surgical intervention between July, 1983 and May, 1994. A total of 25 males and 45 females, with a mean age of 36.9 ± 14.6 years, constituted the sample. Of these, twenty three (33.9%) patients had concurrent thymoma (thymomatous MG), the diagnosis of which was confirmed on the basis of clinical symptoms, Tensilon test, electrophysiological studies or serum acetylcholine receptor antibody (AchR) titer. Also, chest computed tomography was performed to detect the existence of thymoma, and clinical MG staging was determined preoperatively and monitored during the follow-up period. Transsternal extended thymectomy (including mediastinal fat dissection) was undertaken for patients with simple MG, whereas thymothymectomy through sternotomy or sternothoracotomy was undertaken for ones with thymomatous MG. No postoperative death was noted and only two patients, showing MG symptoms, needed prolonged ventilatory support (> 7 days) postoperatively. However, two patients died of thymoma recurrence or metastasis. The outcome (remission and surgical beneficial curve) was analyzed, and the possible influencing factor such as age, sex, existence of thymoma, MG durations before thymectomy, MG staging or the pathology of thymus, was analyzed based ont he univariate and multivariate Cox model. The surgical remission and beneficial rates for the presant patients, at the end of follow-up period, are 35.7% and 87.1% respectively, and the existence of thymoma is found to be the single most significant factor of which adversely influences the outcome. In this series it was also found that younger (< 40 years old) or female patients have significantly higher possibility of acquiring simple MG, than the male or older patients. It may hence be concluded that thymectomy is an effective treatment for patients with MG, and also that patients with thymomatous MG are likely to suffer a worse outcome than the ones with simple MG.
Subjects
Myasthenia gravis; Thymectomy
SDGs

[SDGs]SDG3

Other Subjects
cholinergic receptor; edrophonium chloride; adolescent; adult; aged; article; autoimmune disease; electrodiagnosis; female; human; major clinical study; male; myasthenia gravis; prognosis; provocation test; remission; risk assessment; thymectomy; thymoma; thymus surgery; treatment outcome
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science