Enhancement of the cytotoxicity and selectivity of doxorubicin to hepatoma cells by synergistic combination of galactose-decorated -poly(glutamic acid) nanoparticles and low-intensity ultrasound
Journal
Langmuir
Journal Volume
30
Journal Issue
19
Pages
5510-5517
Date Issued
2014
Author(s)
Abstract
Specific drug delivery to solid tumors remains one of the challenges in cancer therapy. The aim of this study was to combine three drug-targeting strategies, polymer-drug conjugate, ligand presentation and ultrasound treatment, to enhance the efficacy and selectivity of doxorubicin (DXR) to hepatoma cells. The conjugation of DXR to γ-poly(glutamic acids) (γ-PGA) decreased the cytotoxicity of DXR, while the conjugation of galactosamine (Gal) to the γ-PGA-DXR conjugate restored the cytotoxic efficacy of DXR on hepatoma cells due to increased uptake of DXR. Furthermore, low-intensity ultrasound treatment increased the cell-killing ability of γ-PGA-DXR conjugates by 20%. The in vitro results showed the potential of the γ-PGA-DXR-Gal conjugate for future clinical applications. ? 2014 American Chemical Society.
SDGs
Other Subjects
Amino acids; Cytotoxicity; Drug delivery; Ultrasonics; Cancer therapy; Clinical application; Drug-targeting; Hepatoma cells; Low intensity ultrasound; Polyglutamic acids; Synergistic combinations; Ultrasound treatments; Tumors; doxorubicin; galactose; nanoparticle; cell survival; chemistry; drug delivery system; drug effects; human; liver cell carcinoma; tumor cell culture; ultrasound; Carcinoma, Hepatocellular; Cell Survival; Doxorubicin; Drug Delivery Systems; Galactose; Humans; Nanoparticles; Tumor Cells, Cultured; Ultrasonics
Publisher
American Chemical Society
Type
journal article