https://scholars.lib.ntu.edu.tw/handle/123456789/481424
標題: | Effectiveness of bisphosphonate analogues and functional electrical stimulation on attenuating post-injury osteoporosis in spinal cord injury patients- A Systematic Review and Meta-Analysis | 作者: | KE-VIN CHANG Hung C.-Y. WEN-SHIANG CHEN Lai M.-S. KUO-LIONG CHIEN DER-SHENG HAN |
公開日期: | 2013 | 卷: | 8 | 期: | 11 | 起(迄)頁: | e81124 | 來源出版物: | PLoS ONE | 摘要: | Background: Various pharmacologic and non-pharmacologic approaches have been applied to reduce sublesional bone loss after spinal cord injury (SCI), and the results are inconsistent across the studies. The objective of this meta-analysis was to investigate whether the two most-studied interventions, bisphosphonate analogues and functional electrical stimulation (FES), could effectively decrease bone mineral density (BMD) attenuation and/or restore lost BMD in the SCI population. Methods: Randomized controlled trials, quasi-experimental studies, and prospective follow-up studies employing bisphosphonates or FES to treat post-SCI osteoporosis were identified in PubMed and Scopus. The primary outcome was the percentage of BMD change from baseline measured by dual-energy X-ray absorptiometry (DEXA) or computed tomography (CT). Data were extracted from four points: the 3rd, 6th, 12th, and 18th month after intervention. Results: A total of 19 studies were included in the analysis and involved 364 patients and 14 healthy individuals. Acute SCI participants treated with bisphosphonate therapy demonstrated a trend toward less bone loss than participants who received placebos or usual care. A significant difference in BMD decline was noted between both groups at the 3rd and 12th month post-medication. The subgroup analysis failed to show the superiority of intravenous bisphosphonate over oral administration. Regarding FES training, chronic SCI patients had 5.96% (95% CI, 2.08% to 9.84%), 7.21% (95%CI, 1.79% to 12.62%), and 9.56% (95% CI, 2.86% to 16.26%) increases in BMD at the 3rd, 6th, and 12th months post-treatment, respectively. The studies employing FES ?5 days per week were likely to have better effectiveness than studies using FES ?3 days per week. Conclusions: Our meta-analysis indicated bisphosphonate administration early following SCI effectively attenuated sublesional bone loss. FES intervention for chronic SCI patients could significantly increase sublesional BMD near the site of maximal mechanical loading. ? 2013 Chang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896739765&doi=10.1371%2fjournal.pone.0081124&partnerID=40&md5=e26e08882d31652e9f88d36fe70f0778 https://scholars.lib.ntu.edu.tw/handle/123456789/481424 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0081124 | SDG/關鍵字: | alendronic acid; bisphosphonic acid derivative; calcium; etidronic acid; pamidronic acid; placebo; zoledronic acid; bisphosphonic acid derivative; bone density conservation agent; article; bone density; clinical effectiveness; computer assisted tomography; dizziness; drug dosage form comparison; dual energy X ray absorptiometry; fever; flu like syndrome; functional electrical stimulation; gastrointestinal symptom; headache; human; mechanical stress; meta analysis; multiple cycle treatment; myalgia; osteolysis; osteoporosis; rash; spinal cord injury; systematic review; treatment outcome; adverse effects; complication; drug effects; electrostimulation; osteoporosis; procedures; spinal cord injury; Bone Density; Bone Density Conservation Agents; Diphosphonates; Electric Stimulation; Humans; Osteoporosis; Spinal Cord Injuries; Treatment Outcome |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。