Pleural photodynamic therapy and surgery in lung cancer and thymoma patients with pleural spread
Journal
PLoS ONE
Journal Volume
10
Journal Issue
7
Pages
e0133230
Date Issued
2015
Author(s)
Hsieh, Yi-Shan
Tseng, Ying-Fan
Abstract
Pleural spread is difficult to treat in malignancies, especially in lung cancer and thymoma. Monotherapy with surgery fails to have a better survival benefit than palliative chemotherapy, the currently accepted treatment. Photodynamic therapy utilizes a photosensitizer to target the tumor site, and the tumor is exposed to light after performing a pleurectomy and tumor resection. However, the benefits of this procedure to lung cancer or thymoma patients are unknown. We retrospectively reviewed the clinical characteristics and treatment outcomes of patients with lung cancer or thymoma with pleural seeding who underwent pleural photodynamic therapy and surgery between 2005 and 2013. Eighteen patients enrolled in this study. The mean patient age was 52.9 ± 12.2 years. Lung cancer was the inciting cancer of pleural dissemination in 10 patients (55.6%), and thymoma in 8 (44.4%). There was no procedure-related mortality. Using Kaplan-Meier survival analysis, the 3-year survival rate and the 5-year survival rate were 68.9% and 57.4%, respectively.We compared the PDT lung cancer patients with those receiving chemotherapy or target therapy (n = 51) and found that the PDT group had better survival than non-PDT patients (mean survival time: 39.0 versus 17.6 months; P = .047). With proper patient selection, radical surgical resection combined with intrapleural photodynamic therapy for pleural spread in patients with nonsmall cell lung cancer or thymoma is feasible and may provide a survival benefit. ? 2015 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
SDGs
Other Subjects
adjuvant chemoradiotherapy; adult; aged; Article; cancer mortality; cancer surgery; cancer survival; chemoradiotherapy; clinical article; distant metastasis; female; human; length of stay; lung adenocarcinoma; lung cancer; lung lobectomy; male; middle aged; non small cell lung cancer; patient selection; photodynamic therapy; pleura metastasis; survival rate; survival time; thymectomy; thymoma; treatment outcome; disease free survival; Lung Neoplasms; multimodality cancer therapy; pathology; photochemotherapy; pleura; procedures; prognosis; retrospective study; thoracotomy; thymoma; Thymus Neoplasms; Adult; Aged; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Lung Neoplasms; Male; Middle Aged; Photochemotherapy; Pleura; Prognosis; Retrospective Studies; Survival Rate; Thoracotomy; Thymoma; Thymus Neoplasms; Treatment Outcome
Publisher
Public Library of Science
Type
journal article