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  4. Revisit of field cancerization in squamous cell carcinoma of upper aerodigestive tract: Better risk assessment with epigenetic markers
 
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Revisit of field cancerization in squamous cell carcinoma of upper aerodigestive tract: Better risk assessment with epigenetic markers

Journal
Cancer Prevention Research
Journal Volume
4
Journal Issue
12
Pages
1982-1992
Date Issued
2011
Author(s)
YI-CHIA LEE  
HSIU-PO WANG  
CHENG-PING WANG  
JENG-YUH KO  
JANG-MING LEE  
HAN-MO CHIU  
Lin J.-T.
Yamashita S.
Oka D.
Watanabe N.
Matsuda Y.
Ushijima T.
MING-SHIANG WU  
DOI
10.1158/1940-6207.CAPR-11-0096
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-83055167031&doi=10.1158%2f1940-6207.CAPR-11-0096&partnerID=40&md5=13fb7b59d1fd27820f99a590b077d6d4
https://scholars.lib.ntu.edu.tw/handle/123456789/481608
Abstract
We quantified field cancerization of squamous cell carcinoma in the upper aerodigestive tract with epigenetic markers and evaluated their performance for risk assessment. Methylation levels were analyzed by quantitative methylation-specific PCR of biopsied specimens from a training set of 255 patients and a validation set of 224 patients. We also measured traditional risk factors based on demographics, lifestyle, serology, genetic polymorphisms, and endoscopy. The methylation levels of four markers increased stepwise, with the lowest levels in normal esophageal mucosae from healthy subjects without carcinogen exposure, then normal mucosae from healthy subjects with carcinogen exposure, then normal mucosae from cancer patients, and the highest levels were in cancerous mucosae (P < 0.05). Cumulative exposure to alcohol increased methylation of homeobox A9 in normal mucosae (P < 0.01). Drinkers had higher methylation of ubiquitin carboxyl-terminal esterase L1 and metallothionein 1M (P < 0.05), and users of betel quid had higher methylation of homeobox A9 (P = 0.01). Smokers had increased methylation of all four markers (P < 0.05). Traditional risk factors allowed us to discriminate between patients with and without cancers with 74% sensitivity (95% CI: 67%-81%), 74% specificity (66%-82%), and 80% area under the curve (67%-91%); epigenetic markers in normal esophageal mucosa had values of 74% (69%-79%), 75% (67%-83%), and 83% (79%-87%); and both together had values of 82% (76%-88%), 81% (74%-88%), and 91% (88%-94%). Epigenetic markers done well in the validation set with 80% area under the curve (73%-85%). We concluded that epigenetics could improve the accuracies of risk assessment. ?2011 AACR.
SDGs

[SDGs]SDG3

Other Subjects
aldehyde dehydrogenase; aldehyde dehydrogenase isoenzyme 1b; aldehyde dehydrogenase isoenzyme 1c; aldehyde dehydrogenase isoenzyme 2; carcinogen; genomic DNA; glutathione transferase M1; glutathione transferase P1; glutathione transferase T1; metallothionein I; metallothionein Im; neurofilament protein; transcription factor HoxA9; ubiquitin thiolesterase; unclassified drug; adult; aged; article; betel nut; cancer patient; cancer risk; cigarette smoking; controlled study; DNA methylation; epigenetics; esophageal squamous cell carcinoma; esophagoscopy; esophagus mucosa; exposure; female; genetic marker; genetic polymorphism; head and neck cancer; human; human tissue; lifestyle; major clinical study; male; polymerase chain reaction; priority journal; quantitative analysis; risk assessment; sensitivity and specificity; serology; tumor biopsy; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; DNA Methylation; Epigenesis, Genetic; Esophageal Neoplasms; Esophagus; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Mucous Membrane; Polymorphism, Genetic; Prospective Studies; Risk Assessment; Tumor Markers, Biological
Type
journal article

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