https://scholars.lib.ntu.edu.tw/handle/123456789/481646
標題: | The association between microsomal epoxide hydrolase genotypes and esophageal squamous-cell-carcinoma in Taiwan: Interaction between areca chewing and smoking | 作者: | Lin Y.-C. Wu D.-C. JANG-MING LEE Hsu H.-K. Kao E.-L. Yang C.-H. Wu M.-T. |
公開日期: | 2006 | 卷: | 237 | 期: | 2 | 起(迄)頁: | 281-288 | 來源出版物: | Cancer Letters | 摘要: | One hundred and forty-five ESCC patients and 352 controls were recruited from three hospitals in Taiwan to determine the association between esophageal squamous-cell-carcinoma (ESCC) and microsomal epoxide hydrolase (mEH) genotypes at Thy113His and His139Arg. Stratified by their exposures, the His113His genotype was a significant protective factor for ESCC in areca chewers and tobacco smokers. Stratified by His113 polymorphisms, the risk of contracting ESCC for participants with His113His who chewed areca and smoked was >50% less than for those with Thy113Thy. We suggest that the mEH His113His genotype can differentiate the association between smoking, areca chewing, and ESCC. ? 2005 Elsevier Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646846274&doi=10.1016%2fj.canlet.2005.06.010&partnerID=40&md5=fefa437414e53bf3799777fc79edc6c3 https://scholars.lib.ntu.edu.tw/handle/123456789/481646 |
ISSN: | 0304-3835 | DOI: | 10.1016/j.canlet.2005.06.010 | SDG/關鍵字: | epoxide hydrolase; adult; article; betel nut; cancer risk; controlled study; esophagus carcinoma; female; genetic polymorphism; genotype; human; major clinical study; male; mastication; priority journal; smoking; squamous cell carcinoma; statistical analysis; Taiwan; Adult; Areca; Carcinoma, Squamous Cell; Epoxide Hydrolases; Esophageal Neoplasms; Female; Genotype; Humans; Male; Microsomes; Middle Aged; Polymorphism, Genetic; Smoking; Taiwan; Areca; Nicotiana tabacum |
顯示於: | 醫學系 |
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