https://scholars.lib.ntu.edu.tw/handle/123456789/481837
標題: | Human serum RNase-L level is inversely associated with metabolic syndrome and age | 作者: | Wang Y.-T. PING-HUEI TSENG CHI-LING CHEN DER-SHENG HAN Chi Y.-C. FEN-YU TSENG WEI-SHIUNG YANG |
公開日期: | 2017 | 出版社: | BioMed Central Ltd. | 卷: | 16 | 期: | 1 | 起(迄)頁: | 46 | 來源出版物: | Cardiovascular Diabetology | 摘要: | Background: Ribonuclease-L (RNase-L) was known to be a ubiquitous enzyme involved in several cellular functions, especially innate immunity. It was recently shown to participate in adipogenesis in rodents. Here, we developed a method to measure serum levels of RNase-L and analyzed the relationship between RNase-L and metabolic syndrome (MetS). Methods: A total of 396 subjects were recruited from a health check-up program. An in-house RNase-L immunoassay was developed. The serum RNase-L levels of these subjects were measured, and the association of MetS-related factors with RNase-L levels was assessed. Results: The mean serum level of RNase-L of the subjects with MetS were lower than those without (16.5 ± 6.4 vs. 18.4 ± 8.0 μg/ml, P = 0.018). The subjects with central obesity, elevated blood pressure, or impaired fasting glucose also had lower serum RNase-L levels in comparison to those without. In multivariate linear regression analysis, diastolic blood pressure (β = -0.129, P = 0.024) and high-density lipoprotein cholesterol (HDL-C) (β = 0.127, P = 0.036) were related to serum RNase-L. For every 5 μg/ml increase in serum RNase-L levels, it is associated with a reduced risk of MetS (OR 0.83, 95% CI 0.71-0.98, P = 0.028), central obesity (OR 0.82, 95% CI 0.71-0.94, P = 0.005), or low HDL-C (OR 0.86, 95% CI 0.74-1.00, P = 0.042). Moreover, age is inversely related to serum RNase-L levels in various analyses. Conclusions: The serum RNase-L levels were inversely associated with MetS, unfavorable metabolic profiles, and age. ? 2017 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018486306&doi=10.1186%2fs12933-017-0522-x&partnerID=40&md5=03e746c780a82f83be664cfb0922474f https://scholars.lib.ntu.edu.tw/handle/123456789/481837 |
ISSN: | 1475-2840 | DOI: | 10.1186/s12933-017-0522-x | SDG/關鍵字: | antidiabetic agent; antihypertensive agent; antilipemic agent; glucose; high density lipoprotein cholesterol; ribonuclease L; 2-5A-dependent ribonuclease; biological marker; ribonuclease; adult; age; Article; blood analysis; cholesterol blood level; controlled study; diabetes mellitus; diastolic blood pressure; disease association; female; human; hyperlipidemia; hypertension; immunoassay; impaired glucose tolerance; major clinical study; male; medical examination; metabolic syndrome X; middle aged; obesity; risk reduction; aging; anthropometry; blood; enzyme linked immunosorbent assay; metabolic syndrome X; Obesity, Abdominal; pathology; procedures; Adult; Aging; Anthropometry; Biomarkers; Endoribonucleases; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Metabolic Syndrome X; Middle Aged; Obesity, Abdominal |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。