https://scholars.lib.ntu.edu.tw/handle/123456789/481848
標題: | Skeletal muscle mass adjusted by height correlated better with muscular functions than that adjusted by body weight in defining sarcopenia | 作者: | DER-SHENG HAN KE-VIN CHANG Li C.-M. Lin Y.-H. Kao T.-W. KEH-SUNG TSAI TYNG-GUEY WANG WEI-SHIUNG YANG |
公開日期: | 2016 | 出版社: | Nature Publishing Group | 卷: | 6 | 起(迄)頁: | 19457 | 來源出版物: | Scientific Reports | 摘要: | Sarcopenia, characterized by low muscle mass and function, results in frailty, comorbidities and mortality. However, its prevalence varies according to the different criteria used in its diagnosis. This cross-sectional study investigated the difference in the number of sarcopenia cases recorded by two different measurement methods of low muscle mass to determine which measurement was better. We recruited 878 (54.2% female) individuals aged over 65 years and obtained their body composition and functional parameters. Low muscle mass was defined as two standard deviations below either the mean height-adjusted (hSMI) or weight-adjusted (wSMI) muscle mass of a young reference group. The prevalence of sarcopenia was 6.7% vs. 0.4% (male/female) by hSMI, and 4.0% vs. 10.7% (male/female) by wSMI. The κ coefficients for these two criteria were 0.39 vs. 0.03 (male/female), and 0.17 in all subjects. Serum myostatin levels correlated positively with gait speed (r = 0.142, p = 0.007) after adjustment for gender. hSMI correlated with grip strength, cardiopulmonary endurance, leg endurance, gait speed, and flexibility. wSMI correlated with grip strength, leg endurance, gait speed, and flexibility. Since hSMI correlated more closely with grip strength and more muscular functions, we recommend hSMI in the diagnosis of low muscle mass. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955258301&doi=10.1038%2fsrep19457&partnerID=40&md5=ac60854614a16609a6a0457ab8eedbca https://scholars.lib.ntu.edu.tw/handle/123456789/481848 |
ISSN: | 2045-2322 | DOI: | 10.1038/srep19457 | SDG/關鍵字: | adipose tissue; adult; aged; body composition; body weight; case control study; female; fitness; geriatric assessment; human; male; normal human; organ size; pathology; pathophysiology; prevalence; sarcopenia; skeletal muscle; very elderly; young adult; Adipose Tissue; Adult; Aged; Aged, 80 and over; Body Composition; Body Weight; Case-Control Studies; Female; Geriatric Assessment; Healthy Volunteers; Humans; Male; Muscle, Skeletal; Organ Size; Physical Fitness; Prevalence; Sarcopenia; Young Adult |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。