https://scholars.lib.ntu.edu.tw/handle/123456789/482892
標題: | Is Higher Serum Total Cholesterol Level Associated With Better Long-Term Functional Outcomes After Noncardioembolic Ischemic Stroke? | 作者: | SHIN-LIANG PAN Lien I.-N. Chen, Tony Hsiu Hsi |
公開日期: | 2010 | 卷: | 91 | 期: | 6 | 起(迄)頁: | 913-918 | 來源出版物: | Archives of Physical Medicine and Rehabilitation | 摘要: | Pan S-L, Lien I-N, Chen TH. Is higher serum total cholesterol level associated with better long-term functional outcomes after noncardioembolic ischemic stroke? Objective: To investigate the prognostic effects of the serum total cholesterol (TC) levels on long-term functional outcomes in patients with first-time noncardioembolic ischemic stroke. Design: Cohort study. Setting: Referral center. Participants: Patients (N=109) with first-time ischemic stroke. Interventions: Not applicable. Main Outcome Measure: Serial Barthel Index (BI) scores at onset; 2 weeks; and 1, 2, 4, and 6 months after stroke. We analyzed the impact of the serum TC level and other clinical factors on the repeated measurements of BI scores at these 6 time points by using a linear mixed regression model. Results: Taking correlation across repeated measurement of BI scores, the TC level, baseline BI, follow-up time, and infarct size were identified as significant predictors for serial BI scores. Higher TC levels correlated with better functional outcomes. A 1-unit (mmol/L) increase in the TC caused a 3.12 (95% confidence interval [CI], .79-5.46) increase in the BI score after controlling for other clinical factors such as age, baseline functional status, and size of infarct. An elevation of 1 unit of baseline BI led to a .49 increase (95% CI, .38-.59) per unit in subsequent BI scores. A small infarct (<1cm) had higher BI scores than larger infarct by 9.09 (95% CI, 2.03-16.16). Conclusions: The serum TC level measured at the acute stage of noncardioembolic ischemic stroke is an independent predictor for long-term functional outcomes. ? 2010 American Congress of Rehabilitation Medicine. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77952676998&doi=10.1016%2fj.apmr.2010.02.002&partnerID=40&md5=aa00537f37a1cfc5ece4ba93682ea7c1 https://scholars.lib.ntu.edu.tw/handle/123456789/482892 |
ISSN: | 0003-9993 | DOI: | 10.1016/j.apmr.2010.02.002 | SDG/關鍵字: | cholesterol; adult; age; aged; article; brain infarction; brain ischemia; cholesterol blood level; cohort analysis; controlled study; correlation analysis; daily life activity; disease association; female; follow up; functional assessment; human; linear regression analysis; major clinical study; male; prediction; prognosis; scoring system; Serial Barthel Index; Aged; Aspirin; Brain Ischemia; Cholesterol; Cohort Studies; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Linear Models; Longitudinal Studies; Male; Nicotinic Acids; Predictive Value of Tests; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Vasodilator Agents |
顯示於: | 醫學系 |
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