https://scholars.lib.ntu.edu.tw/handle/123456789/484019
標題: | Neutrophil-to-lymphocyte Ratio and Use of Antibiotics Associated With Prognosis in Esophageal Squamous Cell Carcinoma Patients Receiving Immune Checkpoint Inhibitors | 作者: | JHE-CYUAN GUO CHIA-CHI LIN Lin, Chen Yuan MIN-SHU HSIEH HUNG-YANG KUO Lien, Ming Yu YU-YUN SHAO Ta-Chen Huang CHIH-HUNG HSU |
關鍵字: | Antibiotic | esophageal squamous cell carcinoma | neutrophil–to–lymphocyte ratio | prognosis | programmed cell death protein-1;Antibiotic; esophageal squamous cell carcinoma; neutrophil–to–lymphocyte ratio; prognosis; programmed cell death protein-1 | 公開日期: | 1-十月-2019 | 卷: | 39 | 期: | 10 | 來源出版物: | Anticancer research | 摘要: | Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. BACKGROUND/AIM: This study explored the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) and use of antibiotics in advanced esophageal squamous cell carcinoma (ESCC) patients receiving immune checkpoint inhibitors (ICIs). PATIENTS AND METHODS: Patients were enrolled from two referral centers in Taiwan. Clinical benefit was defined as complete response, partial response, or a stable disease for ≥6 months via Response Evaluation Criteria In Solid Tumors 1.1. Clinicopathological factors' impact on overall survival (OS) and progression-free survival (PFS) was analyzed via Cox proportional hazards model. RESULTS: Forty-nine patients were enrolled. The median PFS and OS were 1.8 and 6.1 months, respectively. The median NLR at baseline was 6.40, and 21 patients received antibiotics. Both high NLR and use of antibiotics were associated with inferior PFS (p=0.028 and p<0.001, respectively) and OS (p<0.001 and p<0.001, respectively) in multivariate analysis. CONCLUSION: High NLR and use of antibiotics were associated with inferior survival in advanced ESCC patients receiving ICIs. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/484019 | ISSN: | 0250-7005 1791-7530 |
DOI: | 10.21873/anticanres.13765 | SDG/關鍵字: | antiinfective agent; immunologic factor; adult; aged; drug effect; esophageal squamous cell carcinoma; esophagus tumor; female; human; lymphocyte; male; middle aged; mortality; neutrophil; pathology; prognosis; retrospective study; Taiwan; very elderly; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Humans; Immunologic Factors; Lymphocytes; Male; Middle Aged; Neutrophils; Prognosis; Progression-Free Survival; Retrospective Studies; Taiwan |
顯示於: | 腫瘤醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。