Fatal thrombocytopenia after oxaliplatin-based chemotherapy
Journal
Anticancer Research
Journal Volume
28
Journal Issue
5 B
Pages
3115-3117
Date Issued
2008
Author(s)
Abstract
Oxaliplatin-related thrombocytopenia is considered rare and mostly self-limited. We present the first reported fatal case due to this complication. A 64-year-old patient with metastatic colon cancer was admitted for his 24th course of chemotherapy with oxaliplatin and 24-hour infusion of fluorouracil and leucovorin. Consciousness changed on the next evening and deteriorated to deep coma within hours. Computed tomography revealed large intracranial hemorrhage with brain herniation. Hemogram showed severe thrombocytopenia, which was considered to be associated with oxaliplatin. The patient died six days later. The incidence of oxaliplatin-related thrombocytopenia may have been underestimated and its severity long neglected. Other hypersensitivity reactions may precede its onset. Early hemogram examination during hypersensitivity reaction to oxaliplatin may provide early diagnosis and the prevention of the possible fatal consequences.
SDGs
Other Subjects
antihistaminic agent; fluorouracil; folinic acid; oxaliplatin; steroid; adult; article; brain hernia; case report; chill; colon cancer; computer assisted tomography; human; hypersensitivity reaction; incidence; male; priority journal; rash; thrombocytopenia; tremor; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fatal Outcome; Fluorouracil; Humans; Intracranial Hemorrhages; Male; Middle Aged; Organoplatinum Compounds; Thrombocytopenia
Type
journal article