Zymogen activation, inhibition, and ectodomain shedding of matriptase
Journal
Frontiers in Bioscience
Journal Volume
13
Journal Issue
2
Pages
621-635
Date Issued
2008
Author(s)
DOI
Abstract
Matriptase is a member of an expanding group of type II transmembrane serine proteases. Recently, much has been learned about the biochemistry, cellular biology, normal tissue physiology, and human pathology of this protease, and of its inhibitor, termed the hepatocyte growth factor inhibitor-1 (HAI-1). This review examines the recent literature that has characterized the regulation of matriptase and HAI-1 with an emphasis on the molecular mechanisms governing its zymogen activation, inhibition by HAI-1, and ectodomain shedding.
Type
review