https://scholars.lib.ntu.edu.tw/handle/123456789/485386
標題: | Reworking Organic Synthesis for the Modern Age: Synthetic Strategies Based on Continuous-Flow Addition and Condensation Reactions with Heterogeneous Catalysts | 作者: | Yoo, Woo-Jin Ishitani, Haruro Saito, Yuki Laroche, Benjamin Woo-Jin Yoo |
公開日期: | 17-四月-2020 | 卷: | 85 | 期: | 8 | 來源出版物: | The Journal of organic chemistry | 摘要: | While organic synthesis carried out in most laboratories uses batch methods, there is growing interest in modernizing fine chemical synthesis through continuous-flow processes. As a synthetic method, flow processes have several advantages over batch systems in terms of environmental compatibility, efficiency, and safety, and recent advances have allowed for the synthesis of several complex molecules, including active pharmaceutical ingredients (APIs). Nevertheless, due to several reasons related to the difficulties arising from byproduct formation during the flow process, such as lower yields, poor selectivities, clogging of columns due to poor solubility, catalyst poisoning, etc., successful examples of continuous-flow synthesis of complex organic molecules are still limited. In order to solve this bottleneck, the development of selective and atom-economical continuous-flow organic transformations are needed. This perspective highlights examples of atom-economical addition and condensation reactions with heterogeneous catalysts under continuous-flow conditions and their applications for the synthesis of complex organic molecules such as natural products and APIs. In order to realize new continuous-flow methodologies, based on addition and condensation reactions, in place of substitution reactions, the development of novel reactions and heterogeneous catalysts is required. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/485386 | ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/acs.joc.9b03416 |
顯示於: | 化學系 |
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