https://scholars.lib.ntu.edu.tw/handle/123456789/485696
標題: | Practically acquired and modified cone-beam computed tomography images for accurate dose calculation in head and neck cancer | 作者: | Hu C.-C. Huang W.-T. CHIAO-LING TSAI Wu J.-K. Chao H.-L. Huang G.-M. CHUN-WEI WANG Wu C.-J. CHIA-HSIEN CHENG |
公開日期: | 2011 | 卷: | 187 | 期: | 10 | 起(迄)頁: | 633-644 | 來源出版物: | Strahlentherapie und Onkologie | 摘要: | Background: On-line cone-beam computed tomography (CBCT) may be used to reconstruct the dose for geometric changes of patients and tumors during radiotherapy course. This study is to establish a practical method to modify the CBCT for accurate dose calculation in head and neck cancer. Patients and Methods: Fan-beam CT (FBCT) and Elekta's CBCT were used to acquire images. The CT numbers for different materials on CBCT were mathematically modified to match them with FBCT. Three phantoms were scanned by FBCT and CBCT for image uniformity, spatial resolution, and CT numbers, and to compare the dose distribution from orthogonal beams. A Rando phantom was scanned and planned with intensity-modulated radiation therapy (IMRT). Finally, two nasopharyngeal cancer patients treated with IMRT had their CBCT image sets calculated for dose comparison. Results: With 360° acquisition of CBCT and high-resolution reconstruction, the uniformity of CT number distribution was improved and the otherwise large variations for background and high-density materials were reduced significantly. The dose difference between FBCT and CBCT was < 2% in phantoms. In the Rando phantom and the patients, the dose-volume histograms were similar. The corresponding isodose curves covering ? 90% of prescribed dose on FBCT and CBCT were close to each other (within 2 mm). Most dosimetric differences were from the setup errors related to the interval changes in body shape and tumor response. Conclusion: The specific CBCT acquisition, reconstruction, and CT number modification can generate accurate dose calculation for the potential use in adaptive radiotherapy. ? 2011 Urban & Vogel. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80755171188&doi=10.1007%2fs00066-011-2247-1&partnerID=40&md5=8924267f6c7c1014322515e7e240a945 https://scholars.lib.ntu.edu.tw/handle/123456789/485696 |
ISSN: | 0179-7158 | DOI: | 10.1007/s00066-011-2247-1 | SDG/關鍵字: | article; cancer patient; cancer radiotherapy; case report; cone beam computed tomography; controlled study; dose calculation; dosimetry; histogram; human; image processing; image reconstruction; intensity modulated radiation therapy; nasopharynx cancer; phantom; Cone-Beam Computed Tomography; Humans; Image Processing, Computer-Assisted; Nasopharyngeal Neoplasms; Organs at Risk; Otorhinolaryngologic Neoplasms; Particle Accelerators; Phantoms, Imaging; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated |
顯示於: | 腫瘤醫學研究所 |
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