https://scholars.lib.ntu.edu.tw/handle/123456789/487342
標題: | Weekly 24-hour infusional 5-fluorouracil as initial treatment for advanced gastric cancer with acute disseminated intravascular coagulation | 作者: | TA-CHEN HUANG KUN-HUEI YEH ANN-LII CHENG CHIH-HUNG HSU |
公開日期: | 2008 | 卷: | 28 | 期: | 2 B | 起(迄)頁: | 1293-1297 | 來源出版物: | Anticancer Research | 摘要: | Background: Acute disseminated intravascular coagulation (DIC) occurring in patients with advanced gastric cancer (AGC) is a rare entity with a dismal prognosis. Conventional cytotoxic chemotherapy is usually not possible. Preliminary reports have suggested that non-myelosuppressive weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and leucovorin (HDFL) may be helpful. Patients and Methods: Between 1994 and 2005, AGC patients who presented with acute DIC and were initially treated with HDFL (5-FU 2600 mg/m2 plus leucovorin 300 mg/m2, 24-h infusion weekly) were reviewed. Results: Nineteen such patients were identified. After treatment with HDFL for a median of 4 weeks, 14 patients showed a response of the acute DIC. Eight of them subsequently received HDFL-based combination chemotherapy. The median survivals for the whole group, the DIC responders, and the 8 patients receiving subsequent combination chemotherapy were 3, 6, and 8 months, respectively. Conclusion: HDFL, as a safe initial treatment for AGC patients with acute DIC, provides the opportunity for further aggressive chemotherapy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-42549155675&partnerID=40&md5=25d26901a806a307a717829abb9229ec https://scholars.lib.ntu.edu.tw/handle/123456789/487342 |
ISSN: | 0250-7005 | SDG/關鍵字: | cisplatin; etoposide; fluorouracil; folinic acid; paclitaxel; adult; aged; article; cancer combination chemotherapy; cancer patient; cancer survival; clinical article; disseminated intravascular clotting; female; human; male; priority journal; stomach cancer; treatment duration; Adult; Aged; Antimetabolites, Antineoplastic; Cohort Studies; Disseminated Intravascular Coagulation; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Retrospective Studies; Stomach Neoplasms; Survival Rate |
顯示於: | 腫瘤醫學研究所 |
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