https://scholars.lib.ntu.edu.tw/handle/123456789/487347
標題: | Prognostic Factors for Metastatic Urothelial Carcinoma Treated with Cisplatin and 5-Fluorouracil-Based Regimens | 作者: | CHIA-CHI LIN CHIH-HUNG HSU CHAO-YUAN HUANG YU-CHIEH TSAI KUO-HOW HUANG ANN-LII CHENG YEONG-SHIAU PU |
公開日期: | 2007 | 卷: | 69 | 期: | 3 | 起(迄)頁: | 479-484 | 來源出版物: | Urology | 摘要: | Objectives: We have previously shown that a combination of infusion cisplatin and high-dose 5-fluorouracil/leucovorin (P-HDFL) has moderate activity and acceptable toxicity in patients with metastatic urothelial carcinoma. The present study sought to identify factors that predict for patient survival after treatment with P-HDFL-based regimens. Methods: The outcomes of 79 patients (median age 69 years) with metastatic urothelial cancer treated in two Phase II trials, including P-HDFL and paclitaxel plus P-HDFL, were updated. The log-rank test and multivariate Cox proportional hazard models were used to identify the prognostic factors predicting for survival. Results: The median follow-up duration was 38.9 months (range 10.2 to 89.0). A Karnofsky performance status scale of less than 80% (hazard ratio 2.6, 95% confidence interval 1.5 to 4.6), presence of visceral metastasis (hazard ratio 2.3, 95% confidence interval 1.3 to 4.1), and alkaline phosphatase level of 220 U/L or greater (hazard ratio 2.5, 95% confidence interval 1.3 to 4.5) were three significant risk factors predicting for poor survival in the Cox proportional hazard model. The three factors weighted approximately the same and were independent of each other. The median survival for patients with three, one or two, and no risk factors was 4.6, 13.2, and greater than 81.8 months, respectively (P <0.001). Conclusions: The Karnofsky performance status scale, presence of visceral metastasis, and alkaline phosphatase level were independent risk factors for survival in patients with metastatic urothelial carcinoma treated with cisplatin and 5-fluorouracil-based regimens. ? 2007 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33947254983&doi=10.1016%2fj.urology.2006.12.010&partnerID=40&md5=67e44ffd76c65457210d60d98bbc0288 https://scholars.lib.ntu.edu.tw/handle/123456789/487347 |
ISSN: | 0090-4295 | DOI: | 10.1016/j.urology.2006.12.010 | SDG/關鍵字: | alkaline phosphatase; cisplatin; fluorouracil; folinic acid; paclitaxel; adult; aged; alkaline phosphatase blood level; article; cancer patient; cancer risk; cancer survival; clinical trial; confidence interval; controlled clinical trial; controlled study; female; follow up; human; Karnofsky Performance Status; log rank test; major clinical study; male; multiple cycle treatment; prediction; priority journal; prognosis; proportional hazards model; treatment outcome; urogenital tract cancer; visceral metastasis; Adult; Aged; Alkaline Phosphatase; Antineoplastic Agents; Cisplatin; Female; Fluorouracil; Humans; Karnofsky Performance Status; Kidney Neoplasms; Kidney Pelvis; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Proportional Hazards Models; Risk Factors; Survival Analysis; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms; Urothelium |
顯示於: | 腫瘤醫學研究所 |
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