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  3. Oncology / 腫瘤醫學研究所
  4. Survival outcome of inoperable non-small cell lung cancer patients receiving conventional dose epirubicin and paclitaxel as first-line treatment
 
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Survival outcome of inoperable non-small cell lung cancer patients receiving conventional dose epirubicin and paclitaxel as first-line treatment

Journal
Oncology
Journal Volume
68
Journal Issue
4-6
Pages
350-355
Date Issued
2005
Author(s)
CHIH-HSIN YANG  
Chen M.-C.
ANN-LII CHENG  
CHIH-HUNG HSU  
KUN-HUEI YEH  
Yu Y.-C.
Whang-Peng J.
PAN-CHYR YANG  
DOI
10.1159/000086974
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-23844505957&doi=10.1159%2f000086974&partnerID=40&md5=59159cda570efb63d706780bbad9b3ae
https://scholars.lib.ntu.edu.tw/handle/123456789/487364
Abstract
Objective: High-dose epirubicin was shown to be effective in the treatment of inoperable non-small cell lung cancer (NSCLC). Paclitaxel is synergistic to a conventional dose of anthracyclines in the treatment of advanced cancer. A phase II study was designed to test the effectiveness of combining paclitaxel with a conventional dose of epirubicin in inoperable NSCLC patients. Methods: Eligibility criteria included inoperable stage IIIB or IV NSCLC patients, Eastern Cooperative Oncology Group performance status of 0-2, measurable or evaluable disease and adequate organ function. Epirubicin 70 mg/m2 intravenous infusion for 15 min was given on day 1. Paclitaxel 175 mg/m 2 intravenous infusion for 3 h was given on day 2. Cycles were repeated every 21 days. Tumor response was evaluated every two cycles. Patients received treatment until disease progression, unacceptable toxicity or stable disease after cycle 6. Results: Thirty-eight patients received a total of 185 cycles (median 6 cycles). Seventeen patients responded to treatment (response rate 44.7%). Twenty-six (68%) patients received second-line chemotherapy. All patients were followed until their death. Median survival was 11.9 months (95% confidence interval 9.0-14.9 months). Median time-to-treatment-failure was 4.6 months. Conclusion: Conventional dose epirubicin plus paclitaxel is effective as a first-line treatment for inoperable NSCLC patients. Copyright ? 2004 S. Karger AG.
SDGs

[SDGs]SDG3

Other Subjects
epirubicin; paclitaxel; adult; alopecia; anemia; article; bone pain; cancer chemotherapy; cancer patient; cancer survival; cardiotoxicity; chemotherapy induced emesis; clinical article; clinical trial; confidence interval; controlled clinical trial; controlled study; death; diarrhea; disease course; disease severity; drug efficacy; drug infusion; drug megadose; drug response; female; follow up; human; infection; leukopenia; lung disease; lung non small cell cancer; male; myalgia; nausea; neurotoxicity; neutropenia; phase 2 clinical trial; priority journal; stomatitis; survival rate; survival time; thrombocytopenia; time; toxicity; treatment failure; treatment outcome; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Epirubicin; Female; Humans; Lung Neoplasms; Male; Middle Aged; Paclitaxel; Survival Rate; Treatment Outcome
Type
journal article

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