https://scholars.lib.ntu.edu.tw/handle/123456789/490197
標題: | Treatment outcomes of supraglottoplasty for pediatric obstructive sleep apnea: A meta-analysis | 作者: | Lee, Chia-Fan WEI-CHUNG HSU Lee, Chia-Hsuan Lin, Ming-Tzer Kang, Kun-Tai |
關鍵字: | Child; Epiglottoplasty; Laryngomalacia; Polysomnography; Sleep apnea syndromes; Supraglottoplasty | 公開日期: | 2016 | 卷: | 87 | 起(迄)頁: | 18-27 | 來源出版物: | International Journal of Pediatric Otorhinolaryngology | 摘要: | Objective: To comprehensively review changes in sleep parameters and the success rate of supraglottoplasty for treating obstructive sleep apnea (OSA) in children. In particular, to elucidate treatment modalities and factors affecting treatment outcomes in children with both laryngomalacia and OSA. Methods: The study protocol was registered on PROSPERO (CRD42015027053). Two authors independently searched databases including PubMed, MEDLINE, EMBASE, and the Cochrane Review database. The keywords were "supraglottoplasty," "laryngomalacia," "OSA," "polysomnography," "child," and "humans." Supraglottoplasty served as the primary treatment for OSA or secondary treatment for persistent disease after previous surgeries. Subgroup analyses were conducted for children receiving supraglottoplasty as the primary or secondary treatment for OSA, and for children with and without comorbidities. Results: Eleven studies with 121 patients were analyzed (mean age: 3.7 years; 64% boys; mean sample size: 11 patients). After surgery, the mean differences between the pre- and postoperative measurements were a significant reduction of 8.9 events/h in the apnea-hypopnea index (AHI) and an increase of 3.7% in minimum oxygen saturation (MinSaO2; P < 0.05). The overall success rate was 28% according to a postoperative AHI <1 and 72% according to an AHI <5. Children receiving supraglottoplasty as the primary treatment had significantly younger ages (0.6 vs 6.4 years P < 0.001) than those receiving supraglottoplasty as the secondary treatment, but the outcomes were similar (33% vs 19% for a postoperative AHI < 1, P = 0.27; 77% vs 61% for a postoperative AHI < 5, P = 0.233). Moreover, children with comorbidities, compared with those without, had a similar success rate according to a postoperative AHI <1 (25% vs 21%, P = 0.805) and postoperative AHI <5 (62% vs 84%, P = 0.166). Conclusions: Supraglottoplasty is an effective surgery for AHI reduction and MinSaO2 increase in children with OSA and laryngomalacia. However, complete resolution of OSA is not achieved in most cases, and factors affecting treatment outcomes in these children require future studies. ? 2016 Elsevier Ireland Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/490197 | ISSN: | 0165-5876 | DOI: | 10.1016/j.ijporl.2016.05.015 | SDG/關鍵字: | abscess; apnea hypopnea index; atelectasis; comorbidity; follow up; human; laryngomalacia; larynx surgery; medical device complication; oxygen saturation; polysomnography; postoperative period; preoperative period; priority journal; pulse oximetry; Review; sleep disordered breathing; supraglottoplasty; treatment outcome; adolescent; blood; child; complication; epiglottis; infant; meta analysis; pathophysiology; preschool child; severity of illness index; Sleep Apnea, Obstructive; oxygen; Adolescent; Child; Child, Preschool; Comorbidity; Epiglottis; Humans; Infant; Laryngomalacia; Oxygen; Polysomnography; Postoperative Period; Severity of Illness Index; Sleep Apnea, Obstructive; Treatment Outcome |
顯示於: | 資訊工程學系 |
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