https://scholars.lib.ntu.edu.tw/handle/123456789/490849
標題: | Temporal and spatial temperature distribution in the glabrous skin of rats induced by short-pulse CO2 laser | 作者: | Lu P.-L. Hsu S.-S. Tsai M.-L. FU-SHAN JAW AN-BANG WANG CHEN-TUNG YEN |
公開日期: | 2012 | 卷: | 17 | 期: | 11 | 來源出版物: | Journal of Biomedical Optics | 摘要: | Pain is a natural alarm that aids the body in avoiding potential danger and can also present as an important indicator in clinics. Infrared laser-evoked potentials can be used as an objective index to evaluate nociception. In animal studies, a short-pulse laser is crucial because it completes the stimulation before escape behavior. The objective of the present study was to obtain the temporal and spatial temperature distributions in the skin caused by the irradiation of a short-pulse laser. A fast speed infrared camera was used to measure the surface temperature caused by a CO2 laser of different durations (25 and 35 ms) and power. The measured results were subsequently implemented with a three-layer finite element model to predict the subsurface temperature. We found that stratum corneum was crucial in the modeling of fast temperature response, and escape behaviors correlated with predictions of temperature at subsurface. Results indicated that the onset latency and duration of activated nociceptors must be carefully considered when interpreting physiological responses evoked by infrared irradiation. ? 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870623846&doi=10.1117%2f1.JBO.17.11.117002&partnerID=40&md5=8a31f1c8cca6546ccba601ba06e561c6 https://scholars.lib.ntu.edu.tw/handle/123456789/490849 |
ISSN: | 10833668 | DOI: | 10.1117/1.JBO.17.11.117002 | SDG/關鍵字: | Animal studies; Escape behavior; Finite element modeling; Finite element models; heat pain stimulator; Infra-red cameras; Infra-red irradiation; Laser-evoked; Measured results; Nociception; nociceptors; Physiological response; Short-pulse; Short-pulse lasers; Spatial temperature distribution; Stratum corneum; Subsurface temperature; Surface temperatures; Temperature response; Three-layer; Atmospheric temperature; Electrophysiology; Finite element method; Infrared devices; Infrared lasers; Irradiation; Laser pulses; Temperature distribution; Temperature indicating cameras; Carbon dioxide; Animalia; Rattus; animal; article; biological model; epidermis; escape behavior; finite element analysis; gas laser; heat; infrared radiation; injury; light related phenomena; male; nociception; pain; pain assessment; pathophysiology; physiology; rat; skin temperature; Wistar rat; Animals; Epidermis; Escape Reaction; Finite Element Analysis; Hot Temperature; Infrared Rays; Lasers, Gas; Male; Models, Biological; Nociception; Optical Phenomena; Pain; Pain Measurement; Rats; Rats, Wistar; Skin Temperature |
顯示於: | 應用力學研究所 |
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