https://scholars.lib.ntu.edu.tw/handle/123456789/490891
標題: | Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesia | 作者: | Lee, Ming Tatt Chiu, Yu-Ting YU-CHUN CHIU Hor, Chia Chun Lee, Hsin-Jung Guerrini, Remo Calo, Girolamo LIH-CHU CHIOU |
關鍵字: | Endocannabinoid; Metabotropic glutamate receptor; Neuropeptide S; Orexin; Periaqueductal gray; Substance P | 公開日期: | 9-一月-2020 | 出版社: | BMC | 卷: | 27 | 期: | 1 | 來源出版物: | Journal of biomedical science | 摘要: | Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA, however their causal links remain unclear. Here, we reveal an unprecedented sequential cascade involving these mediators in the lateral hypothalamus (LH) and ventrolateral periaqueductal gray (vlPAG) using a restraint stress-induced SIA model. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/490891 | ISSN: | 1021-7770 | DOI: | 10.1186/s12929-019-0590-1 |
顯示於: | 腦與心智科學研究所 |
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