|Title:||Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesia||Authors:||Lee, Ming Tatt
Hor, Chia Chun
|Keywords:||Endocannabinoid; Metabotropic glutamate receptor; Neuropeptide S; Orexin; Periaqueductal gray; Substance P||Issue Date:||9-Jan-2020||Publisher:||BMC||Journal Volume:||27||Journal Issue:||1||Source:||Journal of biomedical science||Abstract:||
Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA, however their causal links remain unclear. Here, we reveal an unprecedented sequential cascade involving these mediators in the lateral hypothalamus (LH) and ventrolateral periaqueductal gray (vlPAG) using a restraint stress-induced SIA model.
|Appears in Collections:||腦與心智科學研究所|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.