Hispidulin attenuates the social withdrawal in isolated disrupted-in-schizophrenia-1 mutant and chronic phencyclidine-treated mice
Journal
British journal of pharmacology
Date Issued
2020-03-04
Author(s)
Mouri, Akihiro
Lee, Hsin-Jung
Mamiya, Takayoshi
Aoyama, Yuki
Matsumoto, Yurie
Kubota, Hisayoshi
Huang, Wei-Jan
Nabeshima, Toshitaka
Abstract
Hispidulin is a flavonoid isolated from Clerodendrum inerme that was found to inhibit intractable motor tics. Previously, we found that hispidulin attenuates hyperlocomotion and the disrupted prepulse inhibition induced by methamphetamine and N-methyl-d-aspartate (NMDA) receptor antagonists, two phenotypes of schizophrenia resembling positive symptoms. Hispidulin can inhibit COMT, a dopamine-metabolizing enzyme in the prefrontal cortex (PFC) that is important for social interaction. Here, we investigated whether hispidulin would affect social withdrawal, one of the negative symptoms of schizophrenia.
Publisher
WILEY
Type
journal article