In vitro selection of electrochemical peptide probes using bioorthogonal tRNA for influenza virus detection
Journal
Chemical Communications
Journal Volume
54
Journal Issue
41
Pages
5201-5204
Date Issued
2018
Author(s)
Tara Bahadur, K.C.
Tada, S.
Zhu, L.
Uzawa, T.
Minagawa, N.
Luo, S.-C.
Zhao, H.
Yu, H.-H.
Aigaki, T.
Ito, Y.
Abstract
An electrosensitive peptide probe has been developed from an in vitro selection technique using biorthogonal tRNA prepared with an electroreactive non-natural amino acid, 3,4-ethylenedioxythiophene-conjugated aminophenylalanine. The selected probe quantitatively detected the influenza virus based on a signal "turn-on" mechanism. The developed strategy could be used to develop electrochemical biosensors toward a variety of targets.
SDGs
Type
journal article