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  3. Epidemiology and Preventive Medicine / 流行病學與預防醫學研究所
  4. Effect of ventilation improvement during a tuberculosis outbreak in underventilated university buildings
 
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Effect of ventilation improvement during a tuberculosis outbreak in underventilated university buildings

Journal
Indoor Air
Journal Volume
30
Journal Issue
3
Pages
422-432
Date Issued
2020
Author(s)
Du C.-R.
Wang S.-C.
Yu M.-C.
Chiu T.-F.
JANN-YUAN WANG  
Chuang P.-C.
Jou R.
Chan P.-C.
CHI-TAI FANG  
DOI
10.1111/ina.12639
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078031747&doi=10.1111%2fina.12639&partnerID=40&md5=3d7a2f9ff6968e9bdd8930fb22098bc6
https://scholars.lib.ntu.edu.tw/handle/123456789/493725
Abstract
The role of ventilation in preventing tuberculosis (TB) transmission has been widely proposed in infection control guidance. However, conclusive evidence is lacking. Modeling suggested the threshold of ventilation rate to reduce effective reproductive ratio (ratio between new secondary infectious cases and source cases) of TB to below 1 is corresponding to a carbon dioxide (CO2) level of 1000?parts?per?million (ppm). Here, we measured the effect of improving ventilation rate on a TB outbreak involving 27?TB cases and 1665 contacts in underventilated university buildings. Ventilation engineering decreased the maximum CO2 levels from 3204?±?50?ppm to 591-603?ppm. Thereafter, the secondary attack rate of new contacts in university dropped to zero (mean follow-up duration: 5.9?years). Exposure to source TB cases under CO2 >1000?ppm indoor environment was a significant risk factor for contacts to become new infectious TB cases (P?<.001). After adjusting for effects of contact investigation and latent TB infection treatment, improving ventilation rate to levels with CO2 <1000?ppm was independently associated with a 97% decrease (95% CI: 50%-99.9%) in the incidence of TB among contacts. These results show that maintaining adequate indoor ventilation could be a highly effective strategy for controlling TB outbreaks. ? 2019 The Authors. Indoor Air published by John Wiley & Sons Ltd
SDGs

[SDGs]SDG3

Other Subjects
adult; air conditioning; epidemic; female; human; male; tuberculosis; university; Adult; Disease Outbreaks; Female; Humans; Male; Tuberculosis; Universities; Ventilation
Publisher
Blackwell Munksgaard
Type
journal article

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