https://scholars.lib.ntu.edu.tw/handle/123456789/493730
標題: | Risk factors for Kaposi's sarcoma in human immunodeficiency virus patients after initiation of antiretroviral therapy: A nested case–control study in Kenya | 作者: | Lupia R. Wabuyia P.B. Otiato P. CHI-TAI FANG Tsai F.-J. |
公開日期: | 2017 | 出版社: | Elsevier Ltd | 卷: | 50 | 期: | 6 | 起(迄)頁: | 781-788 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background/Purpose This study aimed to evaluate the association between highly active antiretroviral therapy (HAART) adherence and development of Kaposi's sarcoma (KS) in human immunodeficiency virus (HIV)/AIDS patients. Methods We conducted a retrospective nested case–control study of 165 participants (33 cases and 132 controls) receiving HAART care at Maseno Hospital, Kenya, from January 2005 to October 2013. Cases were HIV-positive adults with KS, who were matched with controls in a ratio of 1:4 based on age (±5 years of each case), sex, and KS diagnosis date. Perfect adherence to HAART was assessed on every clinic visit by patients’ self-reporting and pill counts. Chi-square tests were performed to compare socioeconomic and clinical statuses between cases and controls. A conditional logistic regression was used to assess the effects of perfect adherence to HAART, the latest CD4 count, education level, distance to health-care facility, initial World Health Organization stage, and number of regular sexual partners on the development of KS. Results Only 63.6% participants reported perfect adherence, and the control group had a significantly higher percentage of perfect adherence (75.0%) than did cases (18.2%). After adjustment for potential imbalances in the baseline and clinical characteristics, patients with imperfect HAART adherence had 20-times greater risk of developing KS than patients with perfect HAART adherence [hazard ratios: 21.0, 95% confidence interval: 4.2–105.1]. Patients with low latest CD4 count (?350 cells/mm3) had a seven-times greater risk of developing KS than did their counterparts (HRs: 7.1, 95% CI: 1.4–36.2). Conclusion Imperfect HAART adherence and low latest CD4 count are significantly associated with KS development. ? 2015 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84950131602&doi=10.1016%2fj.jmii.2015.10.009&partnerID=40&md5=2a018ff250a186e191217113cac5da2c https://scholars.lib.ntu.edu.tw/handle/123456789/493730 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2015.10.009 | SDG/關鍵字: | antineoplastic agent; antiretrovirus agent; antiretrovirus agent; adult; Article; cancer chemotherapy; cancer risk; cancer staging; case control study; CD4 lymphocyte count; chi square test; confidence interval; controlled study; educational status; female; hazard ratio; health care facility; highly active antiretroviral therapy; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; Kaposi sarcoma; Kenya; logistic regression analysis; major clinical study; male; medication compliance; patient compliance; pill; retrospective study; risk factor; self report; sexuality; social status; world health organization; acquired immune deficiency syndrome; AIDS related complex; highly active antiretroviral therapy; Kaposi sarcoma; middle aged; mixed infection; procedures; risk factor; virology; virus load; Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Case-Control Studies; CD4 Lymphocyte Count; Coinfection; Educational Status; Female; Humans; Kenya; Male; Middle Aged; Patient Compliance; Retrospective Studies; Risk Factors; Sarcoma, Kaposi; Viral Load |
顯示於: | 流行病學與預防醫學研究所 |
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