|Title:||Plasma calcitonin gene-related peptide in diagnosing and predicting paediatric migraine||Authors:||PI-CHUAN FAN
|Keywords:||CGRP; migraine; paediatric; disability||Issue Date:||Aug-2009||Publisher:||SAGE PUBLICATIONS LTD||Journal Volume:||29||Journal Issue:||8||Start page/Pages:||883||Source:||Cephalalgia : an international journal of headache||Abstract:||
To investigate the role of plasma calcitonin gene-related peptide (CGRP) in paediatric migraine, we prospectively collected 134 blood samples during or between attacks from 66 migraine, 33 non-migraine headache (non-migraine) and 22 non-headache patients, aged 4-18 years. Plasma CGRP concentrations were measured by enzyme-linked immunosorbent assay and disability by Pediatric MIgraine Disability ASsessment (PedMIDAS) questionnaire. Migraineurs had higher plasma CGRP levels than non-migraine patients (P = 0.007). The attack level was higher than the non-attack level in migraine (P = 0.036), but not in non-migraine, patients. This was also revealed in paired comparison (n = 9, P = 0.015 vs. n = 4, P = 0.47). Using a threshold of 55.1 pg/ml, the sensitivity of the attack level in predicting migraine was 0.81, and specificity 0.75. The PedMIDAS score tended to be higher in the high CGRP (> 200 pg/ml, n = 7) group than in the low (< 200 pg/ml, n = 33) group (26.07 vs. 19.32, P = 0.16) using Mann-Whitney test. Plasma CGRP is useful for diagnosis in paediatric migraine.
|Appears in Collections:||流行病學與預防醫學研究所|
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