https://scholars.lib.ntu.edu.tw/handle/123456789/494472
標題: | Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin | 作者: | Lai C.-H Chang C.-S Liu H.-H Tsai Y.-S Feng-Ming Hsu Yu Y.-L Lai C.-K Gandee L Pong R.-C Hsu H.-W Yu L Saha D Hsieh J.-T. |
關鍵字: | Cytolethal distending toxin; Ionizing radiation; Prostate cancer; Radio-resistance | 公開日期: | 2014 | 出版社: | Impact Journals LLC | 卷: | 5 | 期: | 14 | 起(迄)頁: | 5523-5534 | 來源出版物: | Oncotarget | 摘要: | Cytolethal distending toxin (CDT) produced by Campylobacter jejuni is a genotoxin that induces cell-cycle arrest and apoptosis in mammalian cells. Recent studies have demonstrated that prostate cancer (PCa) cells can acquire radio-resistance when DOC-2/DAB2 interactive protein (DAB2IP) is downregulated. In this study, we showed that CDT could induce cell death in DAB2IP-deficient PCa cells. A combination of CDT and radiotherapy significantly elicited cell death in DAB2IP-deficient PCa cells by inhibiting the repair of ionizing radiation (IR)-induced DNA double-strand break (DSB) during G2/M arrest, which is triggered by ataxia telangiectasia mutated (ATM)-dependent DNA damage checkpoint responses. We also found that CDT administration significantly increased the efficacy of radiotherapy in a xenograft mouse model. These results indicate that CDT can be a potent therapeutic agent for radio-resistant PCa. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906236187&doi=10.18632%2foncotarget.2133&partnerID=40&md5=c8cb8c80decb6b1b2736c61349157fd6 https://scholars.lib.ntu.edu.tw/handle/123456789/494472 |
ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.2133 | SDG/關鍵字: | ATM protein; cytolethal distending toxin; bacterial toxin; cytolethal distending toxin; DAB2IP protein, human; guanosine triphosphatase activating protein; radiosensitizing agent; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; article; cancer inhibition; cancer radiotherapy; cancer resistance; cell viability; controlled study; double stranded DNA break; drug effect; drug potency; G2 phase cell cycle checkpoint; ionizing radiation; male; mouse; nonhuman; prostate cancer; prostate cancer cell line; radiation dose fractionation; radiosensitivity; sensitization; tumor xenograft; animal; Bagg albino mouse; cell cycle checkpoint; deficiency; drug effects; drug screening; gene silencing; genetics; human; pathology; Prostatic Neoplasms; radiation response; Animals; Apoptosis; Bacterial Toxins; Cell Cycle Checkpoints; Gene Knockdown Techniques; Humans; Male; Mice; Mice, Inbred BALB C; Prostatic Neoplasms; Radiation, Ionizing; Radiation-Sensitizing Agents; ras GTPase-Activating Proteins; Xenograft Model Antitumor Assays |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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