https://scholars.lib.ntu.edu.tw/handle/123456789/494577
標題: | Distant metastasis in triple-negative breast cancer | 作者: | Tseng L.M. Hsu N.C. Chen S.C. YEN-SHEN LU CHING-HUNG LIN DWANG-YING CHANG Li H. Lin Y.C. Chang H.K. Chao T.C. Ouyang F. Hou M.F. |
公開日期: | 2013 | 卷: | 60 | 期: | 3 | 起(迄)頁: | 290-294 | 來源出版物: | Neoplasma | 摘要: | Triple-negative breast cancer (TNBC) relapses more frequently than hormone receptor-positive subtypes and is often associated with poor outcomes. This retrospective study reviewed the pattern of distant metastasis with regard to survival in patients with TNBC. A total of 205 TNBC patients were analyzed. TNBC patients with lung metastases had the longest median post-metastatic OS (with 95% confidence interval) of 16.6 (10.3-22.9) months, followed by the bone, 16.3 (11.7-20.8) months, the liver, 8.9 (3.5-14.4) months, the pleura, 7.5 (2.8-12.3) months, and the brain, 4.3 (0.6-8.0) months. Kaplan-Meier plots indicated that TNBC patients with metastatic spread to brain, liver, and pleural had poorer post-metastatic OS rate than patients with lung metastases (p = 0.001, 0.004, and 0.029, respectively). Moreover, brain and liver metastases correlated significantly with poorer post-metastatic OS as compared to bone metastasis (p = 0.004 and 0.011, respectively). Route of first metastasis correlated significantly with survival of TNBC patients with brain metastases being the poorest survival indicator, followed by metastases to liver, pleura, bone, and lung. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879343177&doi=10.4149%2fneo_2013_038&partnerID=40&md5=fecd5026434267189931fb4a7535adb7 https://scholars.lib.ntu.edu.tw/handle/123456789/494577 |
ISSN: | 0028-2685 | DOI: | 10.4149/neo_2013_038 | SDG/關鍵字: | adult; article; bone metastasis; brain metastasis; distant metastasis; human; liver metastasis; lung metastasis; major clinical study; medical record review; middle aged; overall survival; pleura metastasis; triple negative breast cancer; aged; bone tumor; brain tumor; breast tumor; cancer staging; enzyme immunoassay; female; liver tumor; lung tumor; lymph node metastasis; metabolism; metastasis; mortality; pathology; prognosis; retrospective study; survival rate; very elderly; epidermal growth factor receptor 2; estrogen receptor; progesterone receptor; Adult; Aged; Aged, 80 and over; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Female; Humans; Immunoenzyme Techniques; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Prognosis; Receptor, erbB-2; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Survival Rate |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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