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  4. Clinical outcomes and predictors for ESRD and mortality in primary GN
 
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Clinical outcomes and predictors for ESRD and mortality in primary GN

Journal
Clinical Journal of the American Society of Nephrology
Journal Volume
7
Journal Issue
9
Pages
1401-1408
Date Issued
2012
Author(s)
YU-HSIANG CHOU  
Lien Y.-C.
Hu F.-C.
WEI-CHOU LIN  
Kao C.-C.
CHUN-FU LAI  
WEN-CHIH CHIANG  
SHUEI-LIONG LIN  
TUN-JUN TSAI  
KWAN-DUN WU  
YUNG-MING CHEN  
DOI
10.2215/CJN.04500511
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866113525&doi=10.2215%2fCJN.04500511&partnerID=40&md5=6aad8b7ae59822edc4d7d517e95629c6
https://scholars.lib.ntu.edu.tw/handle/123456789/494866
Abstract
Background and objectives Relatively little is known about the long-termoutcomes of different histologic types of primary glomerulonephritis in Asian populations. Design, setting, participants, & measurements From 1993 to 2006, 987 patients undergoing renal biopsy were studied, and 580 patients (mean age=44.4 years, male=58.5%) with the four most common forms of glomerulonephritis (membranous nephropathy, focal and segmental glomerulosclerosis, IgA nephropathy, and minimal change disease) were selected for analysis. Median follow-up period was 5.9 (interquartile range=5.7) years. Results The focal and segmental glomerulosclerosis group displayed the highest incidence of ESRD (25.8%) and the fastest decline of estimated GFR (4.6 ml/min per 1.73 m2 per year). The IgA nephropathy group also had a higher rate of ESRD than the membranous nephropathy patients (19.2% versus 4.3%, P<0.001). In contrast, the membranous nephropathy group exhibited an overall death rate similar to the focal and segmental glomerulosclerosis group (17.2% versus 14.4%) but higher than the IgA nephropathy and minimal change disease patients (4.6% and 3.7%, respectively, P<0.001). The most powerful predictor for ESRD was focal and segmental glomerulosclerosis, whereas the strongest predictor for all-cause mortality was membranous nephropathy with higher proteinuria. Protectors against ESRD included male sex and higher hemoglobin. Conclusions Most predictors for ESRD and overall mortality found in this ethnic Chinese cohort were similar to other studies. However, some risk factors linked with distinct glomerular pathologies displayed differential clinical outcomes. ? 2012 by the American Society of Nephrology.
SDGs

[SDGs]SDG3

Other Subjects
hemoglobin; adult; article; dialysis; female; focal glomerulonephritis; follow up; glomerulonephritis; glomerulus filtration rate; human; immunoglobulin A nephropathy; kidney biopsy; kidney failure; major clinical study; male; membranous glomerulonephritis; mortality; outcome assessment; prediction; Adult; Aged; Asian Continental Ancestry Group; Biological Markers; Biopsy; Chi-Square Distribution; Disease Progression; Female; Glomerulonephritis; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Hemoglobins; Humans; Incidence; Kaplan-Meier Estimate; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Multivariate Analysis; Nephrosis, Lipoid; Prognosis; Proportional Hazards Models; Proteinuria; Renal Dialysis; Retrospective Studies; Risk Assessment; Risk Factors; Sex Factors; Taiwan; Time Factors; Young Adult
Type
journal article

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